PMID- 38368836
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1719
DP  - 2024 Mar 29
TI  - Simultaneous determination of 58 glucocorticoid residues in milk by ultra-high 
      performance liquid chromatography-tandem mass spectrometry.
PG  - 464734
LID - S0021-9673(24)00107-9 [pii]
LID - 10.1016/j.chroma.2024.464734 [doi]
AB  - Abuse of glucocorticoid veterinary drugs in dairy industry can potentially threat 
      milk safety and consequently influence human health. Here a reliable method for 
      determination of 58 glucocorticoid drug residues in milk was established by 
      combining solid phase extraction with ultra-high performance liquid 
      chromatography-tandem mass spectrometry (UHPLC-MS/MS). The analytes were 
      extracted with acetonitrile and cleanup with EMR-Lipid lipid removal column. The 
      analytes were chromatographically separated using Poroshell EC-C(18) column and 
      acquired by electrospray ionization with multiple-reaction monitoring (MRM) mode. 
      The limit of quantification (S/N >/= 10) ranged from 0.2 to 2.0 microg/kg and the limit 
      of detection (S/N >/= 3) ranged from 0.1 to 1.0 microg/kg. Average recoveries were from 
      71% to 113%, the relative standard deviations (RSDs) were less than 15%, and the 
      correlation coefficients (R(2)) of calibration curves exceeded 0.99. The method 
      was applied to detect twenty milk products obtained from local supermarkets 
      including ten pasteurized milk and ten UHT milk. Two endogenous glucocorticoids, 
      i.e. hydrocortisone and cortisone were detected but not exceed the maximum 
      residue limits (MRLs).
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Guo, Can
AU  - Guo C
AD  - Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business 
      University), Ministry of Education, 100048, PR China; Institute of Quality 
      Standard and Testing Technology for Agro-Products, Chinese Academy of 
      Agricultural Science, Beijing 100081, PR China.
FAU - Wu, Cuiling
AU  - Wu C
AD  - Agilent Technologies Co Ltd China, Beijing 100102, PR China.
FAU - Zhang, Zihao
AU  - Zhang Z
AD  - Agilent Technologies Co Ltd China, Beijing 100102, PR China.
FAU - Tan, Sijia
AU  - Tan S
AD  - Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business 
      University), Ministry of Education, 100048, PR China.
FAU - Chen, Sumeng
AU  - Chen S
AD  - China Agricultural University, Beijing 100193, PR China.
FAU - Chen, Gang
AU  - Chen G
AD  - Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business 
      University), Ministry of Education, 100048, PR China. Electronic address: 
      gang.chen@btbu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240210
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Glucocorticoids)
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Milk/chemistry
MH  - *Tandem Mass Spectrometry/methods
MH  - Glucocorticoids/analysis
MH  - Solid Phase Extraction
MH  - Lipids/analysis
OTO - NOTNLM
OT  - Glucocorticoid
OT  - Liquid chromatography-tandem mass spectrometry
OT  - Milk
COIS- Declaration of competing interest The authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2024/02/19 00:42
MHDA- 2024/03/11 06:43
CRDT- 2024/02/18 18:11
PHST- 2024/01/22 00:00 [received]
PHST- 2024/02/07 00:00 [revised]
PHST- 2024/02/09 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2024/02/19 00:42 [pubmed]
PHST- 2024/02/18 18:11 [entrez]
AID - S0021-9673(24)00107-9 [pii]
AID - 10.1016/j.chroma.2024.464734 [doi]
PST - ppublish
SO  - J Chromatogr A. 2024 Mar 29;1719:464734. doi: 10.1016/j.chroma.2024.464734. Epub 
      2024 Feb 10.