PMID- 38369513
OWN - NLM
STAT- MEDLINE
DCOM- 20240429
LR  - 20240429
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 62
IP  - 6
DP  - 2024 May 27
TI  - Monocyte distribution width (MDW): study of reference values in blood donors.
PG  - 1133-1137
LID - 10.1515/cclm-2023-1495 [doi]
AB  - OBJECTIVES: Monocyte distribution width (MDW) is a new biomarker used as an early 
      indicator of sepsis (ESId). It is often aids in the identification of patients 
      who may develop sepsis. This study aims to establish the MDW reference interval 
      (RI) within the healthy population of blood donors using EDTA-K(2) as 
      anticoagulant. Many hospitals use this biomarker as a means of identifying 
      patients who present to the hospital with sepsis. METHODS: A total of 274 samples 
      obtained from healthy donors were analyzed. MDW measurements were taken within 
      2 h post-extraction. The RI was estimated using various statistical 
      methodologies, including the recommended CLSI EP28-A3c guideline, non-parametric 
      and robust methods, along with the Harrell-Davis bootstrap method applied to the 
      entire sample. RESULTS: The RI estimated through non-parametric method was 14.77 
      CI90 % (14.36-14.97)-21.13 CI90 % (20.89-21.68); RI using the robust method was 
      15.64-19.05 and RI using the Harrell-Davis bootstrap method was 14.73 CI90 % 
      (14.53-14.92)-21.14 CI90 % (20.88-21.40). CONCLUSIONS: Based on clinical 
      applicability, we recommend utilizing the RI derived from the non-parametric 
      method, aligning with the CLSI recommendations. Furthermore, we consider that our 
      results can be taken as a reference in other laboratories that serve a population 
      similar to our study cohort.
CI  - (c) 2024 the author(s), published by De Gruyter, Berlin/Boston.
FAU - Garcia-Alvarez, Ana
AU  - Garcia-Alvarez A
AUID- ORCID: 0000-0002-0451-7184
AD  - Department of Medical Laboratory, Laboratory Medicine Institute, Instituto de 
      Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Hospital Clinico 
      San Carlos, Madrid, Spain.
AD  - Complutense University of Madrid, Faculty of Medicine, Madrid, Spain.
FAU - Posada Franco, Yolanda
AU  - Posada Franco Y
AUID- ORCID: 0009-0000-2854-6919
AD  - Department of Medical Laboratory, Laboratory Medicine Institute, Instituto de 
      Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Hospital Clinico 
      San Carlos, Madrid, Spain.
FAU - Martinez-Novillo Gonzalez, Mercedes
AU  - Martinez-Novillo Gonzalez M
AD  - Department of Medical Laboratory, Laboratory Medicine Institute, Instituto de 
      Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Hospital Clinico 
      San Carlos, Madrid, Spain.
FAU - Hernandez Alvarez, Elena
AU  - Hernandez Alvarez E
AUID- ORCID: 0000-0003-2386-7128
AD  - Department of Medical Laboratory, Laboratory Medicine Institute, Instituto de 
      Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Hospital Clinico 
      San Carlos, Madrid, Spain.
FAU - Serrano Garcia, Irene
AU  - Serrano Garcia I
AUID- ORCID: 0000-0001-7184-5447
AD  - Research Methodological Support Unit, Instituto de Investigacion Sanitaria 
      Hospital Clinico San Carlos (IdISSC), Hospital Clinico San Carlos, Madrid, Spain.
FAU - Sanz-Casla, Maria Teresa
AU  - Sanz-Casla MT
AUID- ORCID: 0000-0002-9184-3497
AD  - Department of Medical Laboratory, Laboratory Medicine Institute, Instituto de 
      Investigacion Sanitaria Hospital Clinico San Carlos (IdISSC), Hospital Clinico 
      San Carlos, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20240219
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Blood Donors
MH  - Reference Values
MH  - Adult
MH  - Male
MH  - Female
MH  - Middle Aged
MH  - *Monocytes/cytology
MH  - Young Adult
MH  - Sepsis/blood/diagnosis
MH  - Biomarkers/blood
MH  - Adolescent
MH  - Aged
OTO - NOTNLM
OT  - anticoagulant EDTA-K2
OT  - donors
OT  - monocyte distribution width (MDW)
OT  - reference interval
OT  - sepsis
EDAT- 2024/02/19 00:42
MHDA- 2024/04/29 13:57
CRDT- 2024/02/18 23:35
PHST- 2023/10/16 00:00 [received]
PHST- 2024/02/01 00:00 [accepted]
PHST- 2024/04/29 13:57 [medline]
PHST- 2024/02/19 00:42 [pubmed]
PHST- 2024/02/18 23:35 [entrez]
AID - cclm-2023-1495 [pii]
AID - 10.1515/cclm-2023-1495 [doi]
PST - epublish
SO  - Clin Chem Lab Med. 2024 Feb 19;62(6):1133-1137. doi: 10.1515/cclm-2023-1495. 
      Print 2024 May 27.