PMID- 38369526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 1738-6055 (Print)
IS  - 2233-7660 (Electronic)
IS  - 1738-6055 (Linking)
VI  - 40
IP  - 1
DP  - 2024 Feb 18
TI  - Naringin from sweet orange peel improves testicular function in high fat 
      diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and 
      maintaining redox balance.
PG  - 5
LID - 10.1186/s42826-024-00188-5 [doi]
LID - 5
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting 
      many organs, including the testis. Naringin from orange peel extract (OPE) is a 
      flavanone with fertility-enhancing properties. Hence, this study was designed to 
      establish the effect of naringin on T2DM-induced testicular dysfunction. Thirty 
      male (30) Wistar rats were randomized into five groups control, diabetes, 
      diabetes + naringin, diabetes + OPE, and diabetes + metformin. The 
      administrations were via the oral route and lasted for 28 days. RESULTS: Naringin 
      ameliorated T2DM-induced increase in FBS and decrease in serum insulin. It also 
      abrogated T2DM-induced decrease in sperm quality, gonadotropin-releasing hormone, 
      luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, 
      prolactin, catalase, superoxide dismutase, and total antioxidant capacity. 
      Furthermore, naringin prevented a T2DM-induced increase in malonaldehyde, tumor 
      necrosis factor-alpha, C-reactive protein, xanthine oxidase (XO), and uric acid 
      (UA), it was accompanied by the restoration of normal testicular 
      histoarchitecture. CONCLUSIONS: Naringin prevented T2DM-induced testicular 
      dysfunction by modulating XO/UA and restoring redox balance. Also, while the 
      animals treated with OPE exhibited better ameliorative effects than their 
      counterparts treated with naringin, the findings from this study showed that 
      naringin would be a promising supplement for treating T2DM-induced male 
      infertility.
CI  - (c) 2024. The Author(s).
FAU - Okesina, Kazeem Bidemi
AU  - Okesina KB
AD  - Department of Medical Physiology, School of Medicine and Pharmacy, College of 
      Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
FAU - Odetayo, Adeyemi Fatai
AU  - Odetayo AF
AUID- ORCID: 0000-0002-9089-7610
AD  - Department of Physiology, Federal University of Health Sciences, Ila Orangun, 
      Nigeria. adeyemiodetayo@gmail.com.
FAU - Adeyemi, Wale Johnson
AU  - Adeyemi WJ
AD  - Department of Physiology, Adeleke University, Ede, Nigeria.
FAU - Ajibare, Ayodeji Johnson
AU  - Ajibare AJ
AD  - Department of Physiology, Lead City University, Ibadan, Nigeria.
FAU - Okesina, Akeem Ayodeji
AU  - Okesina AA
AD  - Department of Clinical Medicine and Community Health, School of Health Sciences, 
      College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
FAU - Olayaki, Luqman Aribidesi
AU  - Olayaki LA
AD  - Department of Physiology, University of Ilorin, Ilorin, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20240218
PL  - England
TA  - Lab Anim Res
JT  - Laboratory animal research
JID - 101560684
PMC - PMC10874537
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Naringin
OT  - Orange peel ethanolic extract
OT  - Redox balance
OT  - Testicular dysfunction
OT  - Xanthine oxidase/uric acid signaling
COIS- The authors have no conflicts of interest to declare.
EDAT- 2024/02/19 00:42
MHDA- 2024/02/19 00:43
PMCR- 2024/02/18
CRDT- 2024/02/18 23:37
PHST- 2023/10/09 00:00 [received]
PHST- 2024/01/15 00:00 [accepted]
PHST- 2024/01/12 00:00 [revised]
PHST- 2024/02/19 00:43 [medline]
PHST- 2024/02/19 00:42 [pubmed]
PHST- 2024/02/18 23:37 [entrez]
PHST- 2024/02/18 00:00 [pmc-release]
AID - 10.1186/s42826-024-00188-5 [pii]
AID - 188 [pii]
AID - 10.1186/s42826-024-00188-5 [doi]
PST - epublish
SO  - Lab Anim Res. 2024 Feb 18;40(1):5. doi: 10.1186/s42826-024-00188-5.