PMID- 38369554
OWN - NLM
STAT- MEDLINE
DCOM- 20240220
LR  - 20240221
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 18
TI  - Quercetin-crosslinked chitosan nanoparticles: a potential treatment for allergic 
      rhinitis.
PG  - 4021
LID - 10.1038/s41598-024-54501-2 [doi]
LID - 4021
AB  - Allergic rhinitis (AR) remains a major health problem worldwide. Compared with 
      traditional oral drugs, nasal administration avoids first-pass metabolism and 
      achieve faster and more effective efficacy. In this study, we used the ion 
      crosslinking method to prepare quercetin-chitosan nasal adaptive nanomedicine 
      (QCS) delivery system and evaluated in the treatment of allergic rhinitis mice 
      models. The obtained positively charged nanoparticles with a particle size of 
      229.2 +/- 0.2 nm have excellent characteristics in encapsulation efficiency 
      (79.604%), drug loading rate (14.068%), drug release (673.068 mug) and 
      stability(> 7 days). Excitingly, QCS treatment significantly reduced the number 
      of sneezing and nasal rubbing events in AR mice, while reducing the levels of 
      inflammatory factors such as immunoglobulin E (IgE), interleukin (IL)-17, tumor 
      necrosis factor (TNF)-alpha, and (IL)-6 to alleviate AR symptoms. Hematoxylin-eosin 
      (HE) staining also showed the damaged nasal mucosa was improved. These 
      experimental results suggest that QCS can effectively suppress allergic 
      inflammation in a mouse model and hold promise as a therapeutic option for 
      allergic rhinitis.
CI  - (c) 2024. The Author(s).
FAU - Mu, Dehong
AU  - Mu D
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Zhou, Li
AU  - Zhou L
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Shi, Lingyu
AU  - Shi L
AD  - Department of Nanchong Vocational College of Science and Technology, Nanchong, 
      637200, People's Republic of China.
FAU - Liu, Ting
AU  - Liu T
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Guo, Ying
AU  - Guo Y
AD  - Department of Clinical Medicine School of Chengdu, University of Traditional 
      Chinese Medicine, Chengdu, 610075, People's Republic of China.
FAU - Chen, Hao
AU  - Chen H
AD  - Department of Clinical Medicine School of Chengdu, University of Traditional 
      Chinese Medicine, Chengdu, 610075, People's Republic of China.
FAU - Luo, Hongping
AU  - Luo H
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Ma, Junhao
AU  - Ma J
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China.
FAU - Xiong, Peizheng
AU  - Xiong P
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China. 
      xiongpeizheng@cdutcm.edu.cn.
FAU - Tian, Li
AU  - Tian L
AD  - Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional 
      Chinese Medicine, Chengdu, 610072, People's Republic of China. 
      18980880129@qq.com.
LA  - eng
GR  - 330023085/Chengdu University of Traditional Chinese Medicine/
PT  - Journal Article
DEP - 20240218
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 9012-76-4 (Chitosan)
RN  - 9IKM0I5T1E (Quercetin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9006-59-1 (Ovalbumin)
RN  - 0 (Cytokines)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Chitosan/pharmacology
MH  - Quercetin/pharmacology
MH  - *Rhinitis, Allergic/metabolism
MH  - Nasal Mucosa/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - *Nanoparticles
MH  - Disease Models, Animal
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/metabolism
MH  - Cytokines/metabolism
PMC - PMC10874938
COIS- The authors declare no competing interests.
EDAT- 2024/02/19 00:42
MHDA- 2024/02/20 11:57
PMCR- 2024/02/18
CRDT- 2024/02/18 23:43
PHST- 2024/01/01 00:00 [received]
PHST- 2024/02/13 00:00 [accepted]
PHST- 2024/02/20 11:57 [medline]
PHST- 2024/02/19 00:42 [pubmed]
PHST- 2024/02/18 23:43 [entrez]
PHST- 2024/02/18 00:00 [pmc-release]
AID - 10.1038/s41598-024-54501-2 [pii]
AID - 54501 [pii]
AID - 10.1038/s41598-024-54501-2 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 18;14(1):4021. doi: 10.1038/s41598-024-54501-2.