PMID- 38370441
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 8
IP  - 3
DP  - 2024 Jan 16
TI  - Low Handgrip Strength (Possible Sarcopenia) With Insulin Resistance Is Associated 
      With Type 2 Diabetes Mellitus.
PG  - bvae016
LID - 10.1210/jendso/bvae016 [doi]
LID - bvae016
AB  - CONTEXT: Older adults with sarcopenic obesity are at high risk for type 2 
      diabetes mellitus (T2DM). However, few East Asians have sarcopenic obesity. Since 
      many East Asians have insulin resistance (IR) without obesity, it is possible 
      that older East Asians with sarcopenia and IR might be at high risk for T2DM. 
      However, this relationship has not been studied. METHODS: This cross-sectional 
      study included 1629 older adults aged 65 to 84 years registered in the Bunkyo 
      Health Study. All underwent a 75-g oral glucose tolerance test and handgrip 
      strength measurement. Participants were classified into 4 groups by possible 
      sarcopenia (handgrip strength <28 kg in men and <18 kg in women) and IR status 
      (triglyceride glucose [TyG] index >/=8.79 for men and >/=8.62 for women [third 
      quartile]). Modified Poisson regression was used to estimate relative risk (RR) 
      and 95% CIs for T2DM with adjustment for confounding factors. RESULTS: The mean 
      age was 73.1 +/- 5.4 years. T2DM was diagnosed in 212 (13.0%) participants. After 
      adjusting for age, sex, body mass index, use of lipid-lowering medications, 
      hypertension, and cardiovascular disease, possible sarcopenia and IR were 
      associated with T2DM, with their coexistence showing a notably stronger 
      association (control: RR, 1.00 [Reference]; possible sarcopenia: RR, 1.55 [95% 
      CI, 1.04-2.30]; IR: RR, 2.69 [95% CI, 1.99-3.65]; and IR possible sarcopenia: RR, 
      4.76 [95% CI, 3.34-6.79]). CONCLUSION: Possible sarcopenia based on low handgrip 
      strength and IR based on the TyG index are independently associated with T2DM in 
      older Japanese individuals. Their coexistence shows a particularly strong 
      association with T2DM.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      Endocrine Society.
FAU - Tajima, Tsubasa
AU  - Tajima T
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Kaga, Hideyoshi
AU  - Kaga H
AUID- ORCID: 0000-0003-0579-2177
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Someya, Yuki
AU  - Someya Y
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
FAU - Tabata, Hiroki
AU  - Tabata H
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
FAU - Naito, Hitoshi
AU  - Naito H
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Kakehi, Saori
AU  - Kakehi S
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
AD  - Sports Medicine & Sportology, Juntendo University Graduate School of Medicine, 
      Tokyo, 113-8421, Japan.
FAU - Ito, Naoaki
AU  - Ito N
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Yamasaki, Nozomu
AU  - Yamasaki N
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Sato, Motonori
AU  - Sato M
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Kadowaki, Satoshi
AU  - Kadowaki S
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Sugimoto, Daisuke
AU  - Sugimoto D
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Nishida, Yuya
AU  - Nishida Y
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
FAU - Kawamori, Ryuzo
AU  - Kawamori R
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
AD  - Sports Medicine & Sportology, Juntendo University Graduate School of Medicine, 
      Tokyo, 113-8421, Japan.
FAU - Watada, Hirotaka
AU  - Watada H
AUID- ORCID: 0000-0001-5961-1816
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
FAU - Tamura, Yoshifumi
AU  - Tamura Y
AUID- ORCID: 0000-0002-1685-7821
AD  - Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, 
      Japan.
AD  - Sportology Center, Juntendo University, Tokyo, 113-8421, Japan.
AD  - Sports Medicine & Sportology, Juntendo University Graduate School of Medicine, 
      Tokyo, 113-8421, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC10872678
OTO - NOTNLM
OT  - handgrip strength
OT  - insulin resistance
OT  - sarcopenia
OT  - triglyceride glucose index
OT  - type 2 diabetes
EDAT- 2024/02/19 06:43
MHDA- 2024/02/19 06:44
PMCR- 2024/02/02
CRDT- 2024/02/19 04:11
PHST- 2023/09/07 00:00 [received]
PHST- 2024/02/19 06:44 [medline]
PHST- 2024/02/19 06:43 [pubmed]
PHST- 2024/02/19 04:11 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - bvae016 [pii]
AID - 10.1210/jendso/bvae016 [doi]
PST - epublish
SO  - J Endocr Soc. 2024 Feb 2;8(3):bvae016. doi: 10.1210/jendso/bvae016. eCollection 
      2024 Jan 16.