PMID- 38371010
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan
TI  - Patient-Reported Outcomes in Pleural Effusions: A Systematic Review.
PG  - e52430
LID - 10.7759/cureus.52430 [doi]
LID - e52430
AB  - Pleural effusions cause breathlessness, decreased activity levels, and impaired 
      quality of life. Clinical trials of drainage of pleural effusion use 
      patient-reported outcome measures (PROMs) to assess these variables. This 
      systematic review aimed to identify which PROMs have been used in clinical trials 
      in pleural effusions, what variables were assessed, whether they were responsive 
      to pleural interventions, and whether they have been validated in patients with 
      pleural effusions, including a defined minimal clinically important difference 
      (MCID). A systematic review was performed to identify relevant clinical trials 
      from Medline, EMBASE, Emcare, and CINAHL and data were extracted. From 329 
      abstracts, 29 clinical trials of pleural effusion drainage that used PROMs as an 
      outcome measure were identified. A total of 16 different PROMs were used. The 
      most used PROMs were unidimensional measurements of breathlessness, particularly 
      the visual analogue scale for dyspnoea (VASD), all of which nearly showed 
      improvements in breathlessness following pleural fluid drainage. Other variables 
      commonly assessed included activity levels and health-related quality of life. 
      Multidimensional PROMs showed inconsistent responsiveness to pleural fluid 
      drainage. Only the VASD was validated in this patient group with a defined MCID. 
      A range of PROMs are used in clinical trials of pleural fluid drainage. No single 
      PROM measures all the outcomes of interest. Unidimensional measurements of 
      breathlessness are responsive to pleural fluid drainage. Only the VASD is 
      validated with an MCID. There is a need for properly validated, response PROMs 
      which measure the key outcomes of interest in this patient group.
CI  - Copyright (c) 2024, Mishra et al.
FAU - Mishra, Eleanor K
AU  - Mishra EK
AD  - Respiratory Medicine, Norfolk and Norwich University Hospitals NHS Foundation 
      Trust, Norwich, GBR.
AD  - Faculty of Medicine and Health Science, University of East Anglia, Norwich, GBR.
FAU - Stanton, Andrew
AU  - Stanton A
AD  - Medicine, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, GBR.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240117
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10870697
OTO - NOTNLM
OT  - breathlessness
OT  - malignant pleural effusion
OT  - patient-reported outcome measure
OT  - pleural effusion
OT  - prom
OT  - quality of life
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/02/19 06:42
MHDA- 2024/02/19 06:43
PMCR- 2024/01/17
CRDT- 2024/02/19 04:20
PHST- 2024/01/03 00:00 [accepted]
PHST- 2024/02/19 06:43 [medline]
PHST- 2024/02/19 06:42 [pubmed]
PHST- 2024/02/19 04:20 [entrez]
PHST- 2024/01/17 00:00 [pmc-release]
AID - 10.7759/cureus.52430 [doi]
PST - epublish
SO  - Cureus. 2024 Jan 17;16(1):e52430. doi: 10.7759/cureus.52430. eCollection 2024 
      Jan.