PMID- 38371187
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 27
IP  - 6
DP  - 2023 Nov-Dec
TI  - Impact of Cardiac Autonomic Dysfunction on Cognitive Event-Related Potential in 
      Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study.
PG  - 506-512
LID - 10.4103/ijem.ijem_368_22 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition 
      that is responsible for various long-term complications. Cognitive impairment is 
      one of the most common complications, but the underlying mechanisms are still 
      undetermined. The autonomic imbalance is a major cause for CVS morbidity in T2DM 
      which could also potentially affect cognition. But there is sparse data available 
      in the literature to prove the association between autonomic dysfunction and 
      cognitive impairment. METHODOLOGY: We recruited 40 T2DM patients and 40 healthy 
      controls. The assessment of cognitive functions was done by cognitive P300 
      event-related potential (ERP) and MoCA. Heart rate variability (HRV) was done to 
      assess autonomic function. RESULTS: The P300 ERP latency in Fz, Cz and Pz sites 
      was significantly prolonged in T2DM patients (P < 0.001). We found moderate 
      correlation is present between P300 latency and total power (r = -0.466, P < 
      0.01) and LFnu (r = -0.423, P < 0.01) in T2DM patients. The total power and HbA1C 
      show independent association with P300 latency after adjustment for confounding 
      factors like age and duration of diabetes (P < 0.05). CONCLUSION: As the 
      incidence of Alzheimer's disease is rising among T2DM patients increasing their 
      dependency, making necessary lifestyle measures at earliest to improve autonomic 
      balance may prevent or delay the onset of cognitive decline and alleviate its 
      consequences and improve the quality of life in T2DM patients.
CI  - Copyright: (c) 2023 Indian Journal of Endocrinology and Metabolism.
FAU - Ramachandran, Madumathy
AU  - Ramachandran M
AD  - Department of Physiology, Saveetha Medical College and Hospital, Chennai, Tamil 
      Nadu, India.
FAU - Priyadarsini, Nibedita
AU  - Priyadarsini N
AD  - Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, 
      Odisha, India.
FAU - Kar, Manisha
AU  - Kar M
AD  - Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, 
      Odisha, India.
FAU - Behera, Kishore Kumar
AU  - Behera KK
AD  - Department of Endocrinology, All India Institute of Medical Sciences, 
      Bhubaneswar, Odisha, India.
LA  - eng
PT  - Journal Article
DEP - 20230630
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC10871012
OTO - NOTNLM
OT  - Autonomic imbalance
OT  - cognitive P300 event-related potential
OT  - cognitive impairment
OT  - heart rate variability
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2024/02/19 06:43
MHDA- 2024/02/19 06:44
PMCR- 2023/11/01
CRDT- 2024/02/19 04:21
PHST- 2022/09/19 00:00 [received]
PHST- 2023/02/10 00:00 [revised]
PHST- 2023/03/23 00:00 [accepted]
PHST- 2024/02/19 06:44 [medline]
PHST- 2024/02/19 06:43 [pubmed]
PHST- 2024/02/19 04:21 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - IJEM-27-506 [pii]
AID - 10.4103/ijem.ijem_368_22 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2023 Nov-Dec;27(6):506-512. doi: 
      10.4103/ijem.ijem_368_22. Epub 2023 Jun 30.