PMID- 38371566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240220
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Print)
IS  - 0019-5154 (Linking)
VI  - 68
IP  - 6
DP  - 2023 Nov-Dec
TI  - Risk of Nephritis and Recurrence in Kimura Disease: A Retrospective Study.
PG  - 611-618
LID - 10.4103/ijd.ijd_670_23 [doi]
AB  - BACKGROUND: Kimura disease (KD) presents a diagnostic challenge to clinicians 
      because of its rarity and atypical symptoms in its early stages, and it is 
      difficult to treat and prone to recurrence or involvement of other organs. AIMS 
      AND OBJECTIVES: This study aims to investigate the possible relevance of renal 
      involvement and recurrence by analysing the clinical presentations, laboratory 
      results, histopathological features, therapeutic data and follow-up results of 
      KD. MATERIALS AND METHODS: A total of 27 patients diagnosed as KD in two 
      hospitals from January 1999 to December 2021 were analysed retrospectively in 
      this study based on the diagnosis of histopathology. RESULTS: KD mainly affected 
      male more than female (8:1) with the onset age ranging from 3 to 58 years (median 
      29.8 years). The common initial symptoms included subcutaneous soft tissue or 
      lymph node enlargement, non-specific skin lesions and proteinuria. One patient 
      presented cough and expectoration as the first symptoms. KD patients often had 
      high levels of serum immunoglobulin E (IgE) and basophils, which exhibited a 
      significantly positive correlation with renal involvement and recurrence (p < 
      0.05). Early mass resection could prevent the development of nephritis and 
      decrease the risk of relapse (p < 0.05). CONCLUSION: KD should be noted in 
      patients presenting with intractable and relapsing atopic skin lesions and (or) 
      subcutaneous mass. Patients with high levels of serum IgE and blood basophils may 
      be prone to developing KD-associated nephritis and predict a high risk of 
      recurrence. Early surgical removal of the mass may result in a better prognosis.
CI  - Copyright: (c) 2023 Indian Journal of Dermatology.
FAU - Zhang, Caiyun
AU  - Zhang C
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
AD  - Department of Medical Cosmetology, Nanjing Hospital of Traditional Chinese 
      Medicine, Nanjing, China.
FAU - Chen, Jun
AU  - Chen J
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Hui, Yun
AU  - Hui Y
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Chen, Huan
AU  - Chen H
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Deng, Dequan
AU  - Deng D
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Sang, Hong
AU  - Sang H
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Liu, Fang
AU  - Liu F
AD  - From the Department of Dermatology, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20240109
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC10869022
OTO - NOTNLM
OT  - Basophils
OT  - Kimura disease
OT  - nephritis
OT  - recurrence
OT  - serum IgE
COIS- There are no conflicts of interest.
EDAT- 2024/02/19 06:43
MHDA- 2024/02/19 06:44
PMCR- 2023/11/01
CRDT- 2024/02/19 04:28
PHST- 2024/02/19 06:44 [medline]
PHST- 2024/02/19 06:43 [pubmed]
PHST- 2024/02/19 04:28 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - IJD-68-611 [pii]
AID - 10.4103/ijd.ijd_670_23 [doi]
PST - ppublish
SO  - Indian J Dermatol. 2023 Nov-Dec;68(6):611-618. doi: 10.4103/ijd.ijd_670_23. Epub 
      2024 Jan 9.