PMID- 38373440
OWN - NLM
STAT- MEDLINE
DCOM- 20240326
LR  - 20240326
IS  - 1476-4180 (Electronic)
IS  - 1476-4172 (Linking)
VI  - 25
IP  - 5-8
DP  - 2023 Nov 17
TI  - Efficacy, tolerance and acceptability of pulsed dye laser on facial and neckline 
      telangiectasias in systemic scleroderma: a prospective open-label monocentric 
      study in 21 patients.
PG  - 77-85
LID - 10.1080/14764172.2024.2313472 [doi]
AB  - Facial and neckline telangiectasias have an underestimated yet important impact 
      on quality of life of patients with systemic scleroderma (SSc). This monocentric, 
      prospective, open-label, intra-patient comparative study was conducted in 21 
      consecutive patients with SSc. Patients underwent 4 sessions of PDL 8 weeks 
      apart. A final quadruple assessment was performed by several raters 2 months 
      after the last session, based on the following criteria: change in telangiectasia 
      number; subjective improvement score (LINKERT scale); impact on the quality of 
      life (QoL; SKINDEX score); visual analog pain scale; adverse effects (AEs), 
      including treatment discontinuation for PDL-induced purpura and patient 
      satisfaction. The mean telangiectasia number decreased by 5 (32%) at the end of 
      the protocol. Eighteen patients (85.7%) reported an improvement or a strong 
      improvement, versus 73.81% for the expert committee. Immediate session pain 
      (mean = 3.4/10) was slightly less than overall pain (mean = 4.6/10). Ten patients 
      (47%) experienced at least one AE (oozing/crusts, edema, epidermal blistering), 
      including PDL-induced purpura in 3 patients (14%). AEs were mostly transient 
      (<1 week) and mild (CTCAE grade 1). All QoL parameters improved after treatment, 
      and 85% of patients were satisfied.
FAU - Kottler, D
AU  - Kottler D
AUID- ORCID: 0000-0002-5952-8796
AD  - Department of Dermatology, Caen, France.
FAU - Dupechez, L
AU  - Dupechez L
AD  - Department of Dermatology, Caen, France.
FAU - Martin Silva, N
AU  - Martin Silva N
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
FAU - Boutemy, J
AU  - Boutemy J
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
FAU - Dumont, A
AU  - Dumont A
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
FAU - Maigne, G
AU  - Maigne G
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
FAU - Aouba, A
AU  - Aouba A
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
FAU - Dompmartin, A
AU  - Dompmartin A
AD  - Department of Internal Medicine, CHU de Caen Normandie, Caen, France.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20240219
PL  - England
TA  - J Cosmet Laser Ther
JT  - Journal of cosmetic and laser therapy : official publication of the European 
      Society for Laser Dermatology
JID - 101136419
SB  - IM
MH  - Humans
MH  - *Lasers, Dye/adverse effects
MH  - Pain
MH  - Prospective Studies
MH  - *Purpura
MH  - Quality of Life
MH  - *Scleroderma, Systemic/complications
MH  - *Telangiectasis/etiology/therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Systemic scleroderma
OT  - facial and neckline telangiectasias
OT  - psychosocial assessment
OT  - pulsed dye laser
OT  - vascular laser
EDAT- 2024/02/20 11:50
MHDA- 2024/03/26 06:45
CRDT- 2024/02/19 19:03
PHST- 2024/03/26 06:45 [medline]
PHST- 2024/02/20 11:50 [pubmed]
PHST- 2024/02/19 19:03 [entrez]
AID - 10.1080/14764172.2024.2313472 [doi]
PST - ppublish
SO  - J Cosmet Laser Ther. 2023 Nov 17;25(5-8):77-85. doi: 
      10.1080/14764172.2024.2313472. Epub 2024 Feb 19.