PMID- 38373761
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240221
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 44
IP  - 2
DP  - 2024 Feb 12
TI  - Acupoint application for postherpetic neuralgia with qi stagnation and blood 
      stasis and its effect on related inflammatory factors and 5-HT.
PG  - 158-162
LID - 10.13703/j.0255-2930.20230628-k0004 [doi]
AB  - OBJECTIVES: To observe the clinical efficacy of acupoint application in treating 
      postherpetic neuralgia(PHN) with qi stagnation and blood stasis, and its effects 
      on serum inflammatory factors and 5-hydroxytryptamine (5-HT) in patients. 
      METHODS: A total of 136 PHN patients were randomly divided into an observation 
      group (68 cases, 6 case dropped out) and a control group (68 cases, 5 cases 
      dropped out). In the observation group, the combination of swelling-reducing and 
      pain-relieving patches and acupoint application with herbal powder was used at 
      bilateral Sanyinjiao (SP 6), Shenque (CV 8) and ashi points. Sanyinjiao (SP 6) 
      was applied for 30 min per session, once every 7 days; and Shenque (CV 8) and 
      ashi points were applied for 6-8 h per session, once every 1 day. In the control 
      group, mecobalamin injection was administered at Jiaji (EX-B 2) corresponding to 
      the neural segments governing the painful area, 1 mL per injection, once a day. 
      Each treatment course consisted of 7 days, 4 treatment courses were required in 
      both groups. The visual analog scale (VAS) score for pain, 36-item short form 
      health survey (SF-36) score, traditional Chinese medicine syndrome score, and the 
      serum levels of inflammatory factors (monocyte chemoattractant protein-1 [MCP-1], 
      interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-alpha]) and 5-HT were compared 
      in the patients of the two groups before and after treatment, and the clinical 
      efficacy was evaluated. RESULTS: After treatment, the VAS scores, traditional 
      Chinese medicine syndrome scores, serum MCP-1, IL-6, TNF-alpha, and 5-HT levels were 
      decreased compared with those before treatment in both groups (P<0.05), and the 
      results in the observation group were lower than those in the control group 
      (P<0.05). The SF-36 scores were increased compared with those before treatment in 
      the two groups (P<0.05), and the result in the observation group was higher than 
      that in the control group (P<0.05). The total effective rate of the observation 
      group was 74.2% (46/62), which was higher than 52.4% (33/63, P<0.05) of the 
      control group. CONCLUSIONS: The combination of swelling-reducing and 
      pain-relieving patches and acupoint application with herbal powder has shown 
      better efficacy in treating PHN with qi stagnation and blood stasis, which can 
      significantly alleviate patients symptoms, improve their quality of life, and 
      reduce serum levels of MCP-1, IL-6, TNF-alpha, and 5-HT.
FAU - Zhu, Shizhuang
AU  - Zhu S
AD  - School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 
      250355, China. 1337199684@qq.com.
FAU - Song, Qingyu
AU  - Song Q
AD  - School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 
      250355, China.
FAU - Liu, Changyue
AU  - Liu C
AD  - School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 
      250355, China.
FAU - Yang, Dianhui
AU  - Yang D
AD  - School of Acupuncture-Moxibustion and Tuina,Shandong University of TCM, Jinan 
      250355, China. jnyangdh@126.com.
AD  - Department of Acupuncture and Moxibustion, Affiliated Hospital of Shandong 
      University of TCM, Jinan 250014. jnyangdh@126.com.
LA  - eng
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - 穴位贴敷治疗气滞血瘀型带状疱疹后遗神经痛及对相关炎性因子、5-HT的影响.
DEP - 20240212
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 333DO1RDJY (Serotonin)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Powders)
SB  - IM
MH  - Humans
MH  - *Neuralgia, Postherpetic/drug therapy
MH  - Qi
MH  - Serotonin
MH  - Acupuncture Points
MH  - Quality of Life
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Powders
OTO - NOTNLM
OT  - 5-hydroxytryptamine (5-HT)
OT  - acupoint application
OT  - acupoint injection
OT  - interleukin-6 (IL-6)
OT  - monocyte chemoattractant protein-1 (MCP-1)
OT  - postherpetic neuralgia (PHN)
OT  - swelling-reducing and pain-relieving patches
OT  - tumor necrosis factor-alpha (TNF-alpha)
EDAT- 2024/02/20 11:50
MHDA- 2024/02/21 11:22
CRDT- 2024/02/19 20:43
PHST- 2024/02/21 11:22 [medline]
PHST- 2024/02/20 11:50 [pubmed]
PHST- 2024/02/19 20:43 [entrez]
AID - 10.13703/j.0255-2930.20230628-k0004 [doi]
PST - epublish
SO  - Zhongguo Zhen Jiu. 2024 Feb 12;44(2):158-162. doi: 
      10.13703/j.0255-2930.20230628-k0004.