PMID- 38375474
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240406
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 15
DP  - 2024
TI  - Tea intake and lung diseases: a Mendelian randomization study.
PG  - 1328933
LID - 10.3389/fimmu.2024.1328933 [doi]
LID - 1328933
AB  - BACKGROUND: Existing studies on the relationship between tea intake and lung 
      diseases have yielded inconsistent results, leading to an ongoing dispute on this 
      issue. The impact of tea consumption on the respiratory system remained 
      elucidating. MATERIALS AND METHODS: We conducted a two-sample Mendelian 
      randomization (MR) study to evaluate the associations between five distinct tea 
      intake phenotypes and 15 different respiratory outcomes using open Genome-wide 
      association study (GWAS) data. The inverse variance weighted (IVW) was used for 
      preliminary screening and a variety of complementary methods were used as 
      sensitivity analysis to validate the robustness of MR estimates. Pathway 
      enrichment analysis was used to explore possible mechanisms. RESULTS: IVW found 
      evidence for a causal effect of standard tea intake on an increased risk of lung 
      squamous cell cancer (LSCC) (OR = 1.004; 95% CI = 1.001-1.007; P = 0.00299). No 
      heterogeneity or pleiotropy was detected. After adjustment for potential 
      mediators, including smoking, educational attainment, and time spent watching 
      television, the association was still robust in multivariable MR. KEGG and GO 
      enrichment predicted proliferation and activation of B lymphocytes may play a 
      role in this causal relation. No causalities were observed when evaluating the 
      effect of other kinds of tea intake on various pulmonary diseases. CONCLUSION: 
      Our MR estimates provide causal evidence of the independent effect of standard 
      tea intake (black tea intake) on LSCC, which may be mediated by B lymphocytes. 
      The results implied that the population preferring black tea intake should be 
      wary of a higher risk of LSCC.
CI  - Copyright (c) 2024 Wu, Jiao, Shu, Li and Zhu.
FAU - Wu, Zhengyan
AU  - Wu Z
AD  - Department of Health Management Center, The First Affiliated Hospital of Soochow 
      University, Suzhou, China.
FAU - Jiao, Min
AU  - Jiao M
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Soochow University, Suzhou, China.
FAU - Shu, Chenying
AU  - Shu C
AD  - College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
FAU - Li, Chang
AU  - Li C
AD  - Department of Pulmonary and Critical Care Medicine, Chongzhou People's Hospital, 
      Chongzhou, China.
FAU - Zhu, Yehan
AU  - Zhu Y
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Soochow University, Suzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240205
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Tea)
SB  - IM
MH  - Genome-Wide Association Study
MH  - Mendelian Randomization Analysis
MH  - *Carcinoma, Non-Small-Cell Lung
MH  - *Carcinoma, Squamous Cell
MH  - *Camellia sinensis
MH  - *Lung Neoplasms/genetics
MH  - Tea
PMC - PMC10875148
OTO - NOTNLM
OT  - Mendelian randomization
OT  - black tea intake
OT  - causal relationship
OT  - green tea intake
OT  - lung diseases
OT  - squamous cell lung cancer
OT  - standard tea intake
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/20 11:50
MHDA- 2024/02/21 11:22
PMCR- 2024/01/01
CRDT- 2024/02/20 03:46
PHST- 2023/10/27 00:00 [received]
PHST- 2024/01/19 00:00 [accepted]
PHST- 2024/02/21 11:22 [medline]
PHST- 2024/02/20 11:50 [pubmed]
PHST- 2024/02/20 03:46 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2024.1328933 [doi]
PST - epublish
SO  - Front Immunol. 2024 Feb 5;15:1328933. doi: 10.3389/fimmu.2024.1328933. 
      eCollection 2024.