PMID- 38376466 OWN - NLM STAT- MEDLINE DCOM- 20240305 LR - 20240305 IS - 2042-650X (Electronic) IS - 2042-6496 (Linking) VI - 15 IP - 5 DP - 2024 Mar 4 TI - Joint associations among non-essential heavy metal mixtures and nutritional factors on glucose metabolism indexes in US adults: evidence from the NHANES 2011-2016. PG - 2706-2718 LID - 10.1039/d3fo05439j [doi] AB - Dietary intake can modify the impact of metals on human health, and is also closely related to glucose metabolism in human bodies. However, research on their interaction is limited. We used data based on 1738 adults aged >/=20 years from the National Health and Nutrition Examination Survey 2011-2016. We combined linear regression and restricted cubic splines with Bayesian kernel machine regression (BKMR) to identify metals associated with each glucose metabolism index (P < 0.05 and the posterior inclusion probabilities of BKMR >0.5) in eight non-essential heavy metals (barium, cadmium, antimony, tungsten, uranium, arsenic, lead, and thallium) and glucose metabolism indexes [fasting plasma glucose (FPG), blood hemoglobin A1c (HbA1c) and homeostatic model assessment of insulin resistance (HOMA-IR)]. We identified two pairs of metals associated with glucose metabolism indexes: cadmium and tungsten to HbA1c and barium and thallium to HOMA-IR. Then, the cross-validated kernel ensemble (CVEK) approach was applied to identify the specific nutrient group (nutrients) that interacted with the association. By using the CVEK model, we identified significant interactions between the energy-adjusted diet inflammatory index (E-DII) and cadmium, tungsten and barium (all P < 0.05); macro-nutrients and cadmium, tungsten and barium (all P < 0.05); minerals and cadmium, tungsten, barium and thallium (all P < 0.05); and A vitamins and thallium (P = 0.043). Furthermore, a lower E-DII, a lower intake of carbohydrates and phosphorus, and a higher consumption of magnesium seem to attenuate the positive association between metals and glucose metabolism indexes. Our finding identifying the nutrients that interact with non-essential heavy metals could provide a feasible nutritional guideline for the general population to protect against the adverse effects of non-essential heavy metals on glucose metabolism. FAU - Chen, Xiaolang AU - Chen X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Li, Peipei AU - Li P AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Huang, Yuanhao AU - Huang Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Lv, Yingnan AU - Lv Y AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Xu, Xia AU - Xu X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Nong, Huiyun AU - Nong H AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Zhang, Lulu AU - Zhang L AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Wu, Huabei AU - Wu H AD - School of General Practice, Guangxi Medical University, Nanning 530021, China. FAU - Yu, Chao AU - Yu C AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Chen, Lina AU - Chen L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Liu, Di AU - Liu D AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Wei, Lancheng AU - Wei L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Zhang, Haiying AU - Zhang H AUID- ORCID: 0000-0002-3823-7498 AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. zhanghaiying@gxmu.edu.cn. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. AD - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China. LA - eng PT - Journal Article DEP - 20240304 PL - England TA - Food Funct JT - Food & function JID - 101549033 RN - 00BH33GNGH (Cadmium) RN - 24GP945V5T (Barium) RN - AD84R52XLF (Thallium) RN - V9306CXO6G (Tungsten) RN - 0 (Glycated Hemoglobin) RN - 0 (Metals, Heavy) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Adult MH - Humans MH - Nutrition Surveys MH - *Cadmium MH - Barium MH - Thallium MH - Tungsten MH - Glycated Hemoglobin MH - Bayes Theorem MH - *Metals, Heavy MH - Glucose EDAT- 2024/02/20 12:51 MHDA- 2024/03/05 06:44 CRDT- 2024/02/20 10:33 PHST- 2024/03/05 06:44 [medline] PHST- 2024/02/20 12:51 [pubmed] PHST- 2024/02/20 10:33 [entrez] AID - 10.1039/d3fo05439j [doi] PST - epublish SO - Food Funct. 2024 Mar 4;15(5):2706-2718. doi: 10.1039/d3fo05439j.