PMID- 38377067
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 2501-062X (Electronic)
IS  - 1220-4749 (Linking)
DP  - 2024 Feb 20
TI  - The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster 
      in type2 diabetic patient.
LID - 10.2478/rjim-2024-0006 [doi]
AB  - Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in 
      inflammation and oxidative stress. It is already known that MCP-1 (Monocyte 
      Chemoattractant Protein-1) and TNF-alpha (tumour necrosis factor) as inflammatory 
      markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial 
      dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in 
      type 2 diabetic patients. The aim of this study was to evaluate the specific 
      biological picture of type 2 diabetic patients that also associate higher GGT 
      activity. Methods. Eighty-five type 2 diabetes, aged 40-70 years with a duration 
      of diabetes less than 6 years without infections, epilepsy, chronic liver or 
      cardiac diseases, without alcohol consumption (>20 g/day) were divided in two 
      subgroups, those with normal and those with high abnormal GGT. Results. The 
      diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher 
      inflammatory markers (CRP, TNF-alpha, MCP-1) and endothelial dysfunction (high leptin 
      and sICAM). sICAM, serum MCP-1 and TNF-alpha levels had significant correlations with 
      GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05). Conclusion. This 
      study underlines that in non-alcoholic diabetic patients, with a duration of the 
      metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-alpha might play an 
      important role in dysmetabolism, and higher level for GGT represents the "red 
      flag" for this condition.
CI  - (c) 2024 Bogdana Virgolici et al., published by Sciendo.
FAU - Virgolici, Bogdana
AU  - Virgolici B
AD  - 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Dobre, Maria Zinaida
AU  - Dobre MZ
AD  - 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Daniela, Lixandru
AU  - Daniela L
AD  - 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Petcu, Laura
AU  - Petcu L
AD  - 2National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, 
      Romania.
FAU - Picu, Ariana
AU  - Picu A
AD  - 2National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, 
      Romania.
FAU - Ionescu-Targoviste, Constantin
AU  - Ionescu-Targoviste C
AD  - 2National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, 
      Romania.
FAU - Greabu, Maria
AU  - Greabu M
AD  - 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Bacanu, Elena Violeta
AU  - Bacanu EV
AD  - 2National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20240220
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
SB  - IM
OTO - NOTNLM
OT  - Tumor Necrosis Factor-alpha
OT  - alanine aminotransferase
OT  - chemoattractant protein 1
OT  - gamma glutamyl transpeptidase
OT  - insulin resistance
OT  - intercellular Adhesion Molecule-1
OT  - monocyte
OT  - oxidative stress
OT  - type 2 diabetes mellitus
EDAT- 2024/02/20 18:42
MHDA- 2024/02/20 18:42
CRDT- 2024/02/20 13:23
PHST- 2024/02/12 00:00 [received]
PHST- 2024/02/20 18:42 [medline]
PHST- 2024/02/20 18:42 [pubmed]
PHST- 2024/02/20 13:23 [entrez]
AID - rjim-2024-0006 [pii]
AID - 10.2478/rjim-2024-0006 [doi]
PST - aheadofprint
SO  - Rom J Intern Med. 2024 Feb 20. doi: 10.2478/rjim-2024-0006.