PMID- 38377302
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
DP  - 2024 Feb 20
TI  - Construction of Smart DNA-Based Drug Delivery Systems for Cancer Therapy.
PG  - e2306257
LID - 10.1002/smll.202306257 [doi]
AB  - Due to the disadvantages of poor targeting, slow action, and low effectiveness of 
      current commonly used cancer treatments, including surgery, chemotherapy, and 
      radiotherapy, researchers have turned to DNA as a biomaterial for constructing 
      drug delivery nanocarriers. DNA is favored for its biocompatibility and 
      programmability. In order to overcome the limitations associated with traditional 
      drug delivery systems (DDSs), researchers have developed smart-responsive DNA 
      DDSs that can control drug release in response to specific physical or chemical 
      stimuli at targeted sites. In this review, a summary of multiple targeted ligand 
      structures is provided, various shapes of stable DNA nanomaterials, and different 
      stimuli-responsive drug release strategies in DNA DDSs. Specifically, targeted 
      cell recognition, in vivo stable transport, and controlled drug release of smart 
      DDSs are focused. Finally, the further development prospects and challenges of 
      clinical application of DNA nanomaterials in the field of smart drug delivery are 
      discussed. The objective of this review is to enhance researchers' comprehension 
      regarding the potential application of DNA nanomaterials in precision drug 
      delivery, with the aim of expediting the clinical implementation of intelligent 
      DDSs.
CI  - (c) 2024 Wiley-VCH GmbH.
FAU - Li, Congcong
AU  - Li C
AD  - Institute for Translational Medicine, The Affiliated Hospital of Qingdao 
      University, College of Medicine, Qingdao University, Qingdao, 266021, China.
FAU - Wang, Mengzhen
AU  - Wang M
AD  - Institute for Translational Medicine, The Affiliated Hospital of Qingdao 
      University, College of Medicine, Qingdao University, Qingdao, 266021, China.
FAU - Li, Pei-Feng
AU  - Li PF
AD  - Institute for Translational Medicine, The Affiliated Hospital of Qingdao 
      University, College of Medicine, Qingdao University, Qingdao, 266021, China.
FAU - Sheng, Junyue
AU  - Sheng J
AD  - Qingdao No.58 High School of Shandong Province, 20 Jiushui Road, Qingdao, 266100, 
      China.
FAU - Fu, Qinrui
AU  - Fu Q
AUID- ORCID: 0000-0003-1334-0349
AD  - Institute for Translational Medicine, The Affiliated Hospital of Qingdao 
      University, College of Medicine, Qingdao University, Qingdao, 266021, China.
LA  - eng
GR  - DC2200002970/Scientific Research of Distinguished Professor from Qingdao 
      University, China/
GR  - DC2200000953/Scientific Research of Distinguished Professor from Qingdao 
      University, China/
GR  - ZR2023QH066/Natural Science Foundation of Shandong Province/
GR  - ZR2023QH045/Natural Science Foundation of Shandong Province/
GR  - 23-2-1-30-zyyd-jch/Natural Science Foundation of Qingdao Municipality, Shandong 
      Province, China/
GR  - tsqnz20230608/Taishan Scholar Project of Shandong Province/
PT  - Journal Article
PT  - Review
DEP - 20240220
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
SB  - IM
OTO - NOTNLM
OT  - DNA nanomaterial
OT  - controlled drug release
OT  - enhanced biological stability
OT  - smart-responsive drug delivery system
OT  - targeted drug delivery
EDAT- 2024/02/20 18:42
MHDA- 2024/02/20 18:42
CRDT- 2024/02/20 14:23
PHST- 2024/02/10 00:00 [revised]
PHST- 2023/07/24 00:00 [received]
PHST- 2024/02/20 18:42 [medline]
PHST- 2024/02/20 18:42 [pubmed]
PHST- 2024/02/20 14:23 [entrez]
AID - 10.1002/smll.202306257 [doi]
PST - aheadofprint
SO  - Small. 2024 Feb 20:e2306257. doi: 10.1002/smll.202306257.