PMID- 38380314
OWN - NLM
STAT- MEDLINE
DCOM- 20240222
LR  - 20240326
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 15
DP  - 2024
TI  - Atopy in chronic urticaria: an important yet overlooked issue.
PG  - 1279976
LID - 10.3389/fimmu.2024.1279976 [doi]
LID - 1279976
AB  - Chronic urticaria (CU) is one of the most common dermatological diseases and has 
      a significant impact on the quality of life of patients. However, the 
      pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous 
      urticaria (CSU) has received considerable attention and has been studied 
      previously. Atopy is an important characteristic of CU; however, it has not been 
      fully recognized. Atopy predisposes individuals to immune responses to allergens, 
      leading to type 2 inflammation and immunoglobulin E (IgE) overproduction. 
      Compared with healthy individuals, patients with CU have a higher proportion of 
      atopy, and an atopic background is correlated with the clinical characteristics 
      of CU. The total IgE levels in patients with CU is significantly higher than 
      those in healthy individuals. Although its level is not higher than that in 
      classic allergic diseases, it is closely related to CU. Exogenous allergens, 
      auto-allergens, and specific IgEs, which are closely related to atopy, have been 
      reported, and their roles in CU pathogenesis are also being studied. Local and 
      systemic atopic inflammation is present in patients with CU. This review 
      summarizes the current knowledge regarding atopy and CU, speculating that there 
      are CU subtypes, such as atopic CSU or atopic chronic inducible urticaria (CIndU) 
      and that atopy may be involved in the pathogenesis of CU. These findings provide 
      a new perspective for a comprehensive understanding of the clinical features of 
      CU and further research regarding its pathogenesis.
CI  - Copyright (c) 2024 Chen, Yang, Ni and Song.
FAU - Chen, Qiquan
AU  - Chen Q
AD  - Department of Dermatology, Southwest Hospital, Army Medical University, 
      Chongqing, China.
FAU - Yang, Xianjie
AU  - Yang X
AD  - Department of Dermatology, Southwest Hospital, Army Medical University, 
      Chongqing, China.
AD  - School of Medicine, Chongqing University, Chongqing, China.
FAU - Ni, Bing
AU  - Ni B
AD  - Department of Pathophysiology, Army Medical University, Chongqing, China.
FAU - Song, Zhiqiang
AU  - Song Z
AD  - Department of Dermatology, Southwest Hospital, Army Medical University, 
      Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20240206
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - *Urticaria
MH  - Quality of Life
MH  - *Chronic Urticaria
MH  - *Hypersensitivity, Immediate/complications
MH  - Allergens
MH  - Immunoglobulin E
MH  - Inflammation/complications
PMC - PMC10876790
OTO - NOTNLM
OT  - IgE
OT  - atopy
OT  - chronic inducible urticaria
OT  - chronic spontaneous urticaria
OT  - chronic urticaria
OT  - mast cell
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/21 11:15
MHDA- 2024/02/22 06:43
PMCR- 2024/01/01
CRDT- 2024/02/21 04:08
PHST- 2023/08/19 00:00 [received]
PHST- 2024/01/22 00:00 [accepted]
PHST- 2024/02/22 06:43 [medline]
PHST- 2024/02/21 11:15 [pubmed]
PHST- 2024/02/21 04:08 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2024.1279976 [doi]
PST - epublish
SO  - Front Immunol. 2024 Feb 6;15:1279976. doi: 10.3389/fimmu.2024.1279976. 
      eCollection 2024.