PMID- 38381160
OWN - NLM
STAT- Publisher
LR  - 20240221
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
DP  - 2024 Feb 21
TI  - Immune recovery uveitis: a focus review.
LID - 10.1007/s00417-024-06415-y [doi]
AB  - Immune recovery uveitis (IRU) is an intraocular inflammation that typically 
      occurs as part of immune reconstitution inflammatory syndrome (IRIS) in the eye. 
      Typically, it affects human immunodeficiency virus (HIV)-infected patients with 
      recognized or unrecognized cytomegalovirus (CMV) retinitis who are receiving 
      highly active antiretroviral therapy (HAART). IRU is a common cause of new vision 
      loss in these patients, and it manifests with a wide range of symptoms and an 
      increased risk of inflammatory complications, such as macular edema. Recently, 
      similar IRU-like responses have been observed in non-HIV individuals with immune 
      reconstitution following immunosuppression of diverse etiologies, posing 
      challenges in diagnosis and treatment. This review provides an updated overview 
      of the current literature on the epidemiology, pathophysiology, biomarkers, 
      clinical manifestations, diagnosis, differential diagnosis, and treatment 
      strategies for IRU.
CI  - (c) 2024. The Author(s).
FAU - Rodrigues Alves, Nuno
AU  - Rodrigues Alves N
AUID- ORCID: 0009-0001-3329-1014
AD  - Department of Ophthalmology, Unidade Local de Saude de Sao Jose, Centro 
      Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, 
      Lisbon, Portugal. nuno.al113@gmail.com.
FAU - Barao, Catarina
AU  - Barao C
AD  - Department of Ophthalmology, Unidade Local de Saude de Sao Jose, Centro 
      Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, 
      Lisbon, Portugal.
FAU - Mota, Catarina
AU  - Mota C
AD  - Department of Ophthalmology, Unidade Local de Saude de Sao Jose, Centro 
      Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, 
      Lisbon, Portugal.
FAU - Costa, Livio
AU  - Costa L
AD  - Department of Ophthalmology, Unidade Local de Saude de Sao Jose, Centro 
      Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, 
      Lisbon, Portugal.
AD  - NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.
FAU - Proenca, Rita Pinto
AU  - Proenca RP
AD  - Department of Ophthalmology, Unidade Local de Saude de Sao Jose, Centro 
      Hospitalar Universitario Lisboa Central, Rua Jose Antonio Serrano, 1150-199, 
      Lisbon, Portugal.
LA  - eng
GR  - ana.quininha@chlc.min-saude.pt/FCCN/b-ON agreement with Springer Nature Open 
      Choice Journal - Transformer Journal - Centro Hospitalar Universitario Lisboa 
      Central/
PT  - Journal Article
PT  - Review
DEP - 20240221
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
OTO - NOTNLM
OT  - Cytomegalovirus retinitis
OT  - Human immunodeficiency virus
OT  - Immune reconstitution inflammatory syndrome
OT  - Immune recovery uveitis
OT  - Uveitis
EDAT- 2024/02/21 12:42
MHDA- 2024/02/21 12:42
CRDT- 2024/02/21 11:05
PHST- 2023/07/30 00:00 [received]
PHST- 2024/02/11 00:00 [accepted]
PHST- 2023/12/23 00:00 [revised]
PHST- 2024/02/21 12:42 [medline]
PHST- 2024/02/21 12:42 [pubmed]
PHST- 2024/02/21 11:05 [entrez]
AID - 10.1007/s00417-024-06415-y [pii]
AID - 10.1007/s00417-024-06415-y [doi]
PST - aheadofprint
SO  - Graefes Arch Clin Exp Ophthalmol. 2024 Feb 21. doi: 10.1007/s00417-024-06415-y.