PMID- 38381368
OWN - NLM
STAT- Publisher
LR  - 20240221
IS  - 1869-4098 (Electronic)
IS  - 1869-408X (Linking)
DP  - 2024 Feb 21
TI  - A Monte Carlo Sensitivity Analysis for a Dimensionally Reduced-Order Model of the 
      Aortic Dissection.
LID - 10.1007/s13239-024-00718-1 [doi]
AB  - PURPOSE: Aortic dissection is associated with a high mortality rate. Although 
      computational approaches have shed light on many aspects of the disease, a 
      sensitivity analysis is required to determine the significance of different 
      factors. Because of its complex geometry and high computational expense, the 
      three-dimensional (3D) fluid-structure interaction (FSI) simulation is not a 
      suitable approach for sensitivity analysis. METHODS: We performed a Monte Carlo 
      simulation (MCS) to investigate the sensitivity of hemodynamic quantities to the 
      lumped parameters of our zero-dimensional (0D) model with numerically calculated 
      lumped parameters. We performed local and global analyses on the effect of the 
      model parameters on important hemodynamic quantities. RESULTS: The MCS showed 
      that a larger lumped resistance value for the false lumen and the tears result in 
      a higher retrograde flow rate in the false lumen (the coefficient of variation, 
      [Formula: see text], the sensitivity [Formula: see text], Spearman's 
      coefficient,[Formula: see text]). For the intraluminal pressure, our results show 
      a significant role in the resistance and inertance of the true lumen (the 
      coefficient of variation, [Formula: see text], the sensitivity [Formula: see 
      text], and Spearman's coefficient,[Formula: see text] for the inertance of the 
      true lumen). CONCLUSION: This study highlights the necessity of comparing the 
      results of the local and global sensitivity analyses to understand the 
      significance of multiple lumped parameters. Because of the efficiency of the 
      method, our approach is potentially useful to investigate and analyze medical 
      planning.
CI  - (c) 2024. The Author(s) under exclusive licence to Biomedical Engineering Society.
FAU - Keramati, Hamed
AU  - Keramati H
AUID- ORCID: 0000-0002-0156-9739
AD  - Integrative Sciences and Engineering Programme (ISEP), National University of 
      Singapore, Singapore, Singapore.
AD  - Department of Biomedical Engineering, National University of Singapore, 
      Singapore, 117576, Singapore.
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, UK.
FAU - Birgersson, Erik
AU  - Birgersson E
AD  - Department of Mechanical Engineering, National University of Singapore, 
      Singapore, 117575, Singapore.
FAU - Kim, Sangho
AU  - Kim S
AD  - Integrative Sciences and Engineering Programme (ISEP), National University of 
      Singapore, Singapore, Singapore.
AD  - Department of Biomedical Engineering, National University of Singapore, 
      Singapore, 117576, Singapore.
FAU - Leo, Hwa Liang
AU  - Leo HL
AD  - Integrative Sciences and Engineering Programme (ISEP), National University of 
      Singapore, Singapore, Singapore. bielhl@nus.edu.sg.
AD  - Department of Biomedical Engineering, National University of Singapore, 
      Singapore, 117576, Singapore. bielhl@nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20240221
PL  - United States
TA  - Cardiovasc Eng Technol
JT  - Cardiovascular engineering and technology
JID - 101531846
SB  - IM
OTO - NOTNLM
OT  - Aortic dissection
OT  - Finite-element method
OT  - Monte Carlo simulation
OT  - Reduced-order model
OT  - Sensitivity analysis
EDAT- 2024/02/21 12:42
MHDA- 2024/02/21 12:42
CRDT- 2024/02/21 11:16
PHST- 2023/02/20 00:00 [received]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/02/21 12:42 [medline]
PHST- 2024/02/21 12:42 [pubmed]
PHST- 2024/02/21 11:16 [entrez]
AID - 10.1007/s13239-024-00718-1 [pii]
AID - 10.1007/s13239-024-00718-1 [doi]
PST - aheadofprint
SO  - Cardiovasc Eng Technol. 2024 Feb 21. doi: 10.1007/s13239-024-00718-1.