PMID- 38383550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240224
IS  - 2373-8057 (Print)
IS  - 2373-8057 (Electronic)
IS  - 2373-8057 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Feb 21
TI  - Coupling between beta band and high frequency oscillations as a clinically useful 
      biomarker for DBS.
PG  - 40
LID - 10.1038/s41531-024-00656-8 [doi]
LID - 40
AB  - Beta hypersynchrony was recently introduced into clinical practice in Parkinson's 
      disease (PD) to identify the best stimulation contacts and for adaptive deep 
      brain stimulation (aDBS) sensing. However, many other oscillopathies accompany 
      the disease, and beta power sensing may not be optimal for all patients. The aim 
      of this work was to study the potential clinical usefulness of beta power 
      phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). 
      Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS 
      electrodes were recorded and analyzed in PD patients (n = 19). Beta power and 
      HFOs were evaluated in a resting-state condition; PAC was then studied and 
      compared with the electrode contact positions, structural connectivity, and 
      medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in 
      all subjects. PAC was detectable more specifically in the motor part of the STN 
      compared to beta power and HFOs. Moreover, the presence of PAC better corresponds 
      to the stimulation setup based on the clinical effect. PAC is also sensitive to 
      the laterality of symptoms and dopaminergic therapy, where the greater PAC 
      cluster reflects the more affected side and medication "off" state. Coupling 
      between beta power and HFOs is known to be a correlate of the PD "off" state. 
      Beta-HFO PAC seems to be more sensitive than beta power itself and could be more 
      helpful in the selection of the best clinical stimulation contact and probably 
      also as a potential future input signal for aDBS.
CI  - (c) 2024. The Author(s).
FAU - Bockova, Martina
AU  - Bockova M
AUID- ORCID: 0000-0003-2691-9122
AD  - Brain and Mind Research Program, Central European Institute of Technology, 
      Masaryk University, Brno, Czech Republic.
AD  - First Department of Neurology, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
FAU - Lamos, Martin
AU  - Lamos M
AUID- ORCID: 0000-0003-1276-4342
AD  - Brain and Mind Research Program, Central European Institute of Technology, 
      Masaryk University, Brno, Czech Republic.
FAU - Chrastina, Jan
AU  - Chrastina J
AD  - Department of Neurosurgery, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
FAU - Daniel, Pavel
AU  - Daniel P
AD  - Brain and Mind Research Program, Central European Institute of Technology, 
      Masaryk University, Brno, Czech Republic.
AD  - First Department of Neurology, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
FAU - Kupcova, Silvia
AU  - Kupcova S
AD  - Faculty of Medicine, Masaryk University, Brno, Czech Republic.
FAU - Riha, Ivo
AU  - Riha I
AD  - Department of Neurosurgery, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
FAU - Smahovska, Lucia
AU  - Smahovska L
AD  - First Department of Neurology, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
AD  - Faculty of Medicine, Masaryk University, Brno, Czech Republic.
FAU - Balaz, Marek
AU  - Balaz M
AD  - Brain and Mind Research Program, Central European Institute of Technology, 
      Masaryk University, Brno, Czech Republic.
AD  - First Department of Neurology, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic.
FAU - Rektor, Ivan
AU  - Rektor I
AUID- ORCID: 0000-0002-9635-7404
AD  - Brain and Mind Research Program, Central European Institute of Technology, 
      Masaryk University, Brno, Czech Republic. ivan.rektor@fnusa.cz.
AD  - First Department of Neurology, Masaryk University School of Medicine, St. Anne's 
      Hospital, Brno, Czech Republic. ivan.rektor@fnusa.cz.
LA  - eng
GR  - 21-25953S/Grantova Agentura Ceske Republiky (Grant Agency of the Czech Republic)/
GR  - 21-25953S/Grantova Agentura Ceske Republiky (Grant Agency of the Czech Republic)/
GR  - 21-25953S/Grantova Agentura Ceske Republiky (Grant Agency of the Czech Republic)/
GR  - 21-25953S/Grantova Agentura Ceske Republiky (Grant Agency of the Czech Republic)/
PT  - Journal Article
DEP - 20240221
PL  - United States
TA  - NPJ Parkinsons Dis
JT  - NPJ Parkinson's disease
JID - 101675390
PMC - PMC10882016
COIS- The authors declare no competing interests.
EDAT- 2024/02/22 00:42
MHDA- 2024/02/22 00:43
PMCR- 2024/02/21
CRDT- 2024/02/21 23:46
PHST- 2023/07/28 00:00 [received]
PHST- 2024/02/07 00:00 [accepted]
PHST- 2024/02/22 00:43 [medline]
PHST- 2024/02/22 00:42 [pubmed]
PHST- 2024/02/21 23:46 [entrez]
PHST- 2024/02/21 00:00 [pmc-release]
AID - 10.1038/s41531-024-00656-8 [pii]
AID - 656 [pii]
AID - 10.1038/s41531-024-00656-8 [doi]
PST - epublish
SO  - NPJ Parkinsons Dis. 2024 Feb 21;10(1):40. doi: 10.1038/s41531-024-00656-8.