PMID- 38383579
OWN - NLM
STAT- MEDLINE
DCOM- 20240223
LR  - 20240224
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 21
TI  - Directed functional connectivity of the default-mode-network of young and older 
      healthy subjects.
PG  - 4304
LID - 10.1038/s41598-024-54802-6 [doi]
LID - 4304
AB  - Alterations in the default mode network (DMN) are associated with aging. We 
      assessed age-dependent changes of DMN interactions and correlations with a 
      battery of neuropsychological tests, to understand the differences of DMN 
      directed connectivity between young and older subjects. Using a novel 
      multivariate analysis method on resting-state functional MRI data from fifty 
      young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 
      4-nodes directed pathways. For the old subject group, we calculated the partial 
      correlations of inter-DMN pathways with: psychomotor speed and working memory, 
      executive function, language, long-term memory and visuospatial function. 
      Pathways connecting the DMN with visual and limbic regions in older subjects 
      engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex 
      (PCC), whereas in young subjects, they were at high frequency and involved the 
      ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM 
      efferent in the young subjects and SM afferent in the older subjects. Most DMN 
      efferent pathways correlated with reduced speed and working memory. We suggest 
      that the reduced sensorimotor efferent and the increased need to control such 
      activities, cause a higher dependency on external versus internal cues thus 
      suggesting how physical activity might slow aging.
CI  - (c) 2024. The Author(s).
FAU - Goelman, Gadi
AU  - Goelman G
AD  - Department of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew 
      University Medical Center, 91120, Jerusalem, Israel. gadig@hadassah.org.il.
AD  - Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. 
      gadig@hadassah.org.il.
FAU - Dan, Rotem
AU  - Dan R
AD  - Department of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew 
      University Medical Center, 91120, Jerusalem, Israel.
AD  - Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of 
      Jerusalem, Jerusalem, Israel.
FAU - Bezdicek, Ondrej
AU  - Bezdicek O
AD  - Department of Neurology and Center of Clinical Neuroscience, Charles University, 
      Prague, Czech Republic.
FAU - Jech, Robert
AU  - Jech R
AD  - Department of Neurology and Center of Clinical Neuroscience, Charles University, 
      Prague, Czech Republic.
FAU - Ekstein, Dana
AU  - Ekstein D
AD  - Department of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew 
      University Medical Center, 91120, Jerusalem, Israel.
AD  - Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
LA  - eng
GR  - AZV: NV19-04-00233/Ministerstvo Zdravotnictvi Ceske Republiky/
GR  - AZV: NV19-04-00233/Ministerstvo Zdravotnictvi Ceske Republiky/
PT  - Journal Article
DEP - 20240221
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Brain/diagnostic imaging
MH  - *Brain Mapping/methods
MH  - Healthy Volunteers
MH  - Memory, Short-Term
MH  - Aging
MH  - Neural Pathways
MH  - Magnetic Resonance Imaging/methods
PMC - PMC10881992
OTO - NOTNLM
OT  - Aging
OT  - Default mode network
OT  - Directed functional connectivity MRI
OT  - Multivariate analysis
OT  - Neuropsychological tests
COIS- The authors declare no competing interests.
EDAT- 2024/02/22 00:43
MHDA- 2024/02/23 06:43
PMCR- 2024/02/21
CRDT- 2024/02/21 23:48
PHST- 2023/10/25 00:00 [received]
PHST- 2024/02/16 00:00 [accepted]
PHST- 2024/02/23 06:43 [medline]
PHST- 2024/02/22 00:43 [pubmed]
PHST- 2024/02/21 23:48 [entrez]
PHST- 2024/02/21 00:00 [pmc-release]
AID - 10.1038/s41598-024-54802-6 [pii]
AID - 54802 [pii]
AID - 10.1038/s41598-024-54802-6 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 21;14(1):4304. doi: 10.1038/s41598-024-54802-6.