PMID- 38384614
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240224
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan
TI  - Autologous Conditioned Plasma (ACP) and Osteoarthritis of the Knee: A Review of 
      Current Clinical Evidence.
PG  - e52693
LID - 10.7759/cureus.52693 [doi]
LID - e52693
AB  - The primary objective of this study is to record the clinical outcomes of 
      autologous conditioned plasma (ACP) for the treatment of knee osteoarthritis (OA) 
      based on published literature. Multiple databases (PubMed, Embase, Web of Science 
      and Scopus) were searched using terms for "knee OA" and the intervention "ACP" 
      for articles published in English to January 4, 2024. All clinical studies using 
      ACP for knee OA were included. Studies not utilizing ACP alone, i.e. used as an 
      adjunct with other modalities or not focusing on the management of knee OA, were 
      excluded. Five studies, three randomized controlled trials (RCTs) and two 
      real-world post-market studies conducted in a clinical practice met the 
      inclusion/exclusion criteria and were included in this study. All studies 
      demonstrated statistically significant improvements in various patient-reported 
      outcome measures (PROMs), however the studies performed in the clinical practice 
      reported non-accomplishment of minimally clinically important difference (MCID). 
      The results demonstrated the potential of ACP for management of knee OA, however 
      the MCID was not achieved in real-world clinical settings. Thus, more adequately 
      powered RCTs with longer follow-up as well as real-world post-market studies are 
      warranted to establish long-term efficacy and justify routine clinical use, 
      respectively, of ACP in patients suffering with knee OA.
CI  - Copyright (c) 2024, Gupta et al.
FAU - Gupta, Ashim
AU  - Gupta A
AD  - Regenerative Medicine, Future Biologics, Lawrenceville, USA.
AD  - Regenerative Medicine, BioIntegrate, Lawrenceville, USA.
AD  - Orthopaedics, South Texas Orthopaedic Research Institute, Laredo, USA.
AD  - Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida, IND.
FAU - Jain, Vijay
AU  - Jain V
AD  - Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar 
      Lohia Hospital, New Delhi, IND.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240121
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10879647
OTO - NOTNLM
OT  - acp
OT  - acp max
OT  - autologous conditioned plasma
OT  - gonarthrosis
OT  - knee osteoarthritis
OT  - leukocyte-poor platelet-rich plasma
OT  - lp prp
OT  - orthobiologics
OT  - platelet-rich plasma
OT  - prp
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/02/22 06:43
MHDA- 2024/02/22 06:44
PMCR- 2024/01/21
CRDT- 2024/02/22 03:52
PHST- 2024/01/21 00:00 [accepted]
PHST- 2024/02/22 06:44 [medline]
PHST- 2024/02/22 06:43 [pubmed]
PHST- 2024/02/22 03:52 [entrez]
PHST- 2024/01/21 00:00 [pmc-release]
AID - 10.7759/cureus.52693 [doi]
PST - epublish
SO  - Cureus. 2024 Jan 21;16(1):e52693. doi: 10.7759/cureus.52693. eCollection 2024 
      Jan.