PMID- 38386276
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
DP  - 2024 Feb 22
TI  - Calorie restriction protects against acute systemic LPS-induced inflammation.
PG  - 1-13
LID - 10.1080/1028415X.2024.2316448 [doi]
AB  - Caloric restriction (CR) has been proposed as a nutritional strategy to combat 
      chronic diseases, including neurodegenerative diseases, as well as to delay 
      aging. However, despite the benefits of CR, questions remain about its underlying 
      mechanisms and cellular and molecular targets.Objective: As inflammatory 
      processes are the basis or accompany chronic diseases and aging, we investigated 
      the protective role of CR in the event of an acute inflammatory stimulus.Methods: 
      Peripheral inflammatory and metabolic parameters were evaluated in Wistar rats 
      following CR and/or acute lipopolysaccharide (LPS) administration, as well as 
      glial changes (microglia and astrocytes), in two regions of the brain 
      (hippocampus and hypothalamus) involved in the inflammatory response. We used a 
      protocol of 30% CR, for 4 or 8 weeks. Serum and brain parameters were analyzed by 
      biochemical or immunological assays.Results: Benefits of CR were observed during 
      the inflammatory challenge, where the partial reduction of serum interleukin-6, 
      mediated by CR, attenuated the systemic response. In the central nervous system 
      (CNS), specifically in the hippocampus, CR attenuated the response to the LPS, as 
      evaluated by tumor necrosis factor alpha (TNFalpha) levels. Furthermore, in the 
      hippocampus, CR increased the glutathione (GSH) levels, resulting in a better 
      antioxidant response.Discussion: This study contributes to the understanding of 
      the effects of CR, particularly in the CNS, and expands knowledge about glial 
      cells, emphasizing their importance in neuroprotection strategies.
FAU - da Silva, Vanessa-Fernanda
AU  - da Silva VF
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Gayger-Dias, Vitor
AU  - Gayger-Dias V
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - da Silva, Rafaela Sampaio
AU  - da Silva RS
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Sobottka, Thomas Michel
AU  - Sobottka TM
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Cigerce, Anderson
AU  - Cigerce A
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Lissner, Lilian Juliana
AU  - Lissner LJ
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
AD  - Dipartimento di Fisiologia e Farmacologia "Vittorio Erspamer", Universita degli 
      Studi di Roma "La Sapienza", Piazzale Aldo Moro, Rome.
FAU - Wartchow, Krista Mineia
AU  - Wartchow KM
AD  - Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 
      New York, NY, USA.
FAU - Rodrigues, Leticia
AU  - Rodrigues L
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Zanotto, Caroline
AU  - Zanotto C
AD  - Biochemistry Laboratory, Grupo Hospitalar Conceicao, Porto Alegre, Brazil.
FAU - Froes, Fernanda Carolina Telles da Silva
AU  - Froes FCTDS
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Seady, Marina
AU  - Seady M
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Quincozes-Santos, Andre
AU  - Quincozes-Santos A
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
FAU - Goncalves, Carlos-Alberto
AU  - Goncalves CA
AD  - Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciencias Basicas 
      da Saude (ICBS), Graduate Program in Biochemistry, Porto Alegre, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20240222
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
SB  - IM
OTO - NOTNLM
OT  - Astrocyte
OT  - GFAP
OT  - Hippocampus
OT  - LPS
OT  - caloric restriction
OT  - inflammation
OT  - microglia
OT  - neuroprotection
EDAT- 2024/02/22 12:43
MHDA- 2024/02/22 12:43
CRDT- 2024/02/22 11:16
PHST- 2024/02/22 12:43 [medline]
PHST- 2024/02/22 12:43 [pubmed]
PHST- 2024/02/22 11:16 [entrez]
AID - 10.1080/1028415X.2024.2316448 [doi]
PST - aheadofprint
SO  - Nutr Neurosci. 2024 Feb 22:1-13. doi: 10.1080/1028415X.2024.2316448.