PMID- 38387108
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 54
IP  - 1
DP  - 2024 Feb
TI  - Efficacy and safety of transcranial direct current stimulation in the treatment 
      of fibromyalgia: A systematic review and meta-analysis.
PG  - 102944
LID - S0987-7053(24)00002-9 [pii]
LID - 10.1016/j.neucli.2024.102944 [doi]
AB  - OBJECTIVES: To update a systematic review of the efficacy and safety of 
      transcranial direct current stimulation (tDCS) for analgesia, for antidepressant 
      effects, and to reduce the impact of fibromyalgia (FM), looking for optimal areas 
      of stimulation. METHODS: We searched five databases to identify randomized 
      controlled trials comparing active and sham tDCS for FM. The primary outcome was 
      pain intensity, and secondary outcome measures included FM Impact Questionnaire 
      (FIQ) and depression score. Meta-analysis was conducted using standardized mean 
      difference (SMD). Subgroup analysis was performed to determine the effects of 
      different regional stimulation, over the primary motor cortex (M1), dorsolateral 
      prefrontal cortex (DLPFC), opercular-insular cortex (OIC), and occipital nerve 
      (ON) regions. We analyzed the minimal clinically important difference (MCID) by 
      the value of the mean difference (MD) for an 11-point scale for pain, the Beck 
      Depressive Inventory-II (BDI-II), and the Fibromyalgia Impact Questionnaire (FIQ) 
      score. We described the certainty of the evidence (COE) using the tool GRADE 
      profile. RESULTS: Twenty studies were included in the analysis. Active tDCS had a 
      positive effect on pain (SMD= -1.04; 95 % CI -1.38 to -0.69), depression (SMD= 
      -0.46; 95 % CI -0.64 to -0.29), FIQ (SMD= -0.73; 95 % CI -1.09 to -0.36), COE is 
      moderate. Only group M1 (SD=-1.57) and DLPFC (SD=-1.44) could achieve MCID for 
      analgesia; For BDI-II, only group DLPFC (SD=-5.36) could achieve an MCID change. 
      Adverse events were mild. CONCLUSION: tDCS is a safe intervention that relieves 
      pain intensity, reduces depression, and reduces the impact of FM on life. 
      Achieving an MCID is related to the stimulation site and the target symptom.
CI  - Copyright (c) 2024 The Author(s). Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Yang, Chun-Lan
AU  - Yang CL
AD  - Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, China; Department 
      of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 
      610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in Sichuan 
      Province, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, 
      China.
FAU - Qu, Yun
AU  - Qu Y
AD  - Department of Rehabilitation Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in 
      Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan, China.
FAU - Huang, Jia-Peng
AU  - Huang JP
AD  - Department of Rehabilitation Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in 
      Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan, China.
FAU - Wang, Ting-Ting
AU  - Wang TT
AD  - Department of Rehabilitation Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in 
      Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan, China.
FAU - Zhang, Han
AU  - Zhang H
AD  - Department of Rehabilitation Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in 
      Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan, China.
FAU - Chen, Yin
AU  - Chen Y
AD  - Department of Rehabilitation Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China; Key Laboratory of Rehabilitation Medicine in 
      Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan, China.
FAU - Tan, Ying-Chao
AU  - Tan YC
AD  - Enshi Prefecture Central Hospital, Enshi 445000, Hubei, China. Electronic 
      address: 363802014@qq.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20240221
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
MH  - Humans
MH  - *Fibromyalgia/therapy/complications
MH  - Pain/etiology
MH  - Pain Management
MH  - *Transcranial Direct Current Stimulation
OTO - NOTNLM
OT  - Adverse event
OT  - Depression
OT  - Fibromyalgia
OT  - Fibromyalgia impact questionnaire
OT  - Pain
OT  - tDCS
COIS- Declaration of competing interest None reported.
EDAT- 2024/02/22 18:43
MHDA- 2024/03/05 06:47
CRDT- 2024/02/22 18:00
PHST- 2023/08/04 00:00 [received]
PHST- 2024/01/04 00:00 [revised]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/03/05 06:47 [medline]
PHST- 2024/02/22 18:43 [pubmed]
PHST- 2024/02/22 18:00 [entrez]
AID - S0987-7053(24)00002-9 [pii]
AID - 10.1016/j.neucli.2024.102944 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2024 Feb;54(1):102944. doi: 10.1016/j.neucli.2024.102944. Epub 
      2024 Feb 21.