PMID- 38389296
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240229
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 30
DP  - 2024 Feb 23
TI  - Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender 
      Differences in GST-pi Excretion.
PG  - e942819
LID - 10.12659/MSM.942819 [doi]
AB  - BACKGROUND Serum creatinine, the criterion standard in assessment of renal 
      function, is not reliable for the neonatal period because of its dependence on 
      renal immaturity and maternal creatinine levels. Thus, it is important to study 
      other biomarkers of renal function in neonates. The present study aimed to 
      measure the urinary concentration of renal biomarkers: calbindin, clusterin, 
      GST-pi (glutathione-S-transferase-alpha), KIM-1 (kidney injury molecule 1), MCP-1 
      (monocyte chemoattractant protein-1), and B2M (beta 2-microglobulin) in healthy 
      term neonates. MATERIAL AND METHODS In the study, we included 80 healthy term 
      neonates - 40 females and 40 males. We collected the neonates' urine on their 
      first day of life. Urinary concentrations of calbindin, clusterin, KIM-1, MCP-1, 
      and B2M were assessed using an immunoassay for kidney toxicology research. 
      Because dilution of the urine affects the concentrations of urinary biomarkers, 
      we normalized them to the concentration of urinary creatinine (Cr) and present 
      them as biomarker/Cr ratios. RESULTS We obtained the following values of the 
      assessed biomarker/Cr ratios (median [Q1-Q3]): calbindin/Cr.: 197.04 
      (56.25-595.17), KIM-1/Cr: 0.09 (0.04-0.18), MCP-1/Cr: 0.05 (0.02-0.14), B2M/Cr: 
      126.12 (19.03-342.48), GST-pi/Cr in boys: 1.28 (0.46-3.77), GST-pi/Cr in girls: 
      8.66 (2.51-27.82), clusterin/Cr: 4.55 (1.79-12.97) ng/mg Cr. CONCLUSIONS We 
      showed the urinary levels of calbindin, clusterin, GST-pi, KIM-1, MCP-1, B2M in 
      white, West Slavic, healthy term neonates. We found that in there is an 
      association between female sex and a higher urinary GST-pi excretion, but urinary 
      excretion of calbindin, clusterin, KIM-1, MCP-1, and B2M is sex-independent. The 
      urinary levels of the assessed biomarkers do not depend on the method of 
      delivery.
FAU - Kamianowska, Monika
AU  - Kamianowska M
AUID- ORCID: 0000-0002-7756-5419
AD  - Department of Neonatology and Neonatal Intensive Care, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Rybi-Szuminska, Agnieszka
AU  - Rybi-Szuminska A
AUID- ORCID: 0000-0003-1890-6997
AD  - Department of Pediatrics and Nephrology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Kamianowska, Aleksandra
AU  - Kamianowska A
AD  - Department of Pediatrics and Nephrology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Maciejczyk, Mateusz
AU  - Maciejczyk M
AUID- ORCID: 0000-0001-5609-3187
AD  - Department of Hygiene, Epidemiology and Ergonomics, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Zubrzycka, Anna
AU  - Zubrzycka A
AUID- ORCID: 0000-0002-5015-1865
AD  - Department of Neonatology and Neonatal Intensive Care, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Nazarko, Joanna
AU  - Nazarko J
AD  - Department of Neonatology and Neonatal Intensive Care, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Wasilewska, Anna
AU  - Wasilewska A
AUID- ORCID: 0000-0003-0257-4422
AD  - Department of Pediatrics and Nephrology, Medical University of Bialystok, 
      Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20240223
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Clusterin)
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Biomarkers)
RN  - 0 (Calbindins)
SB  - IM
MH  - Male
MH  - Infant, Newborn
MH  - Humans
MH  - Female
MH  - *Clusterin
MH  - Creatinine
MH  - Sex Factors
MH  - *Kidney
MH  - Biomarkers
MH  - Calbindins
PMC - PMC10898192
COIS- Conflict of interest: None declared
EDAT- 2024/02/23 06:43
MHDA- 2024/02/26 06:45
PMCR- 2024/02/23
CRDT- 2024/02/23 01:23
PHST- 2024/02/26 06:45 [medline]
PHST- 2024/02/23 06:43 [pubmed]
PHST- 2024/02/23 01:23 [entrez]
PHST- 2024/02/23 00:00 [pmc-release]
AID - 942819 [pii]
AID - 10.12659/MSM.942819 [doi]
PST - epublish
SO  - Med Sci Monit. 2024 Feb 23;30:e942819. doi: 10.12659/MSM.942819.