PMID- 38389821 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240224 IS - 2674-0001 (Electronic) IS - 2674-0001 (Linking) VI - 3 DP - 2023 TI - E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs. PG - 11345 LID - 10.3389/adar.2023.11345 [doi] LID - 11345 AB - Electronic cigarettes (e-cigarettes) are devices that allow the user to inhale nicotine in a vapor, and are primarily marketed as a means of quitting smoking and a less harmful replacement for traditional cigarette smoking. However, further research is needed to determine if vaping nicotine via e-cigarettes can be effective. Conversely, nicotine has been considered a gateway drug to alcohol and other addictive drugs and e-cigarettes containing nicotine may have the same effects. Previous reports have shown that e-cigarette use may open the gate for the use of other drugs including conventional cigarettes, cannabis, opioids, etc. The increasing prevalence of e-cigarettes, particularly among youth and adolescents in the last decade have led to an increase in the dual use of e-cigarettes with alcohol, cannabis, and other illicit drug use like heroin and 3-4-methylenedioxymethamphetamine (MDMA). The advent of e-cigarettes as a device to self-administer addictive agents such as cocaine and synthetic cathinones may bring about additional adverse health effects associated with their concurrent use. This review aims to briefly describe e-cigarettes and their different generations, and their co-use with other addictive drugs as well as the use of the device as a tool to self-administer addictive drugs, such as cocaine, etc. CI - Copyright (c) 2023 Chen, Rahman and Lutfy. FAU - Chen, Grace AU - Chen G AD - College of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA, United States. FAU - Rahman, Shafiqur AU - Rahman S AD - Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, United States. FAU - Lutfy, Kabirullah AU - Lutfy K AD - College of Pharmacy, Western University of Health Sciences, Pomona, CA, United States. LA - eng PT - Journal Article PT - Review DEP - 20230630 PL - Switzerland TA - Adv Drug Alcohol Res JT - Advances in drug and alcohol research JID - 9918335075006676 PMC - PMC10880776 OTO - NOTNLM OT - addictive drugs OT - adolescents OT - alcohol OT - cannabis OT - conventional cigarettes OT - e-cig OT - gateway OT - smoking cessation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/02/23 06:43 MHDA- 2024/02/23 06:44 PMCR- 2023/06/30 CRDT- 2024/02/23 03:48 PHST- 2023/03/08 00:00 [received] PHST- 2023/06/14 00:00 [accepted] PHST- 2024/02/23 06:44 [medline] PHST- 2024/02/23 06:43 [pubmed] PHST- 2024/02/23 03:48 [entrez] PHST- 2023/06/30 00:00 [pmc-release] AID - 11345 [pii] AID - 10.3389/adar.2023.11345 [doi] PST - epublish SO - Adv Drug Alcohol Res. 2023 Jun 30;3:11345. doi: 10.3389/adar.2023.11345. eCollection 2023.