PMID- 38390180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240224
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 4
DP  - 2024 Feb 29
TI  - Risk factor analysis and nomogram for predicting gastroparesis in patients with 
      type 2 diabetes mellitus.
PG  - e26221
LID - 10.1016/j.heliyon.2024.e26221 [doi]
LID - e26221
AB  - PURPOSE: The incidence of gastroparesis is higher in individuals diagnosed with 
      type 2 diabetes mellitus (T2DM) compared to the healthy individuals. Our study 
      aimed to explore the risk factors for gastroparesis in T2DM and to establish a 
      clinical prediction model (nomogram). METHODS: Our study enlisted 694 patients 
      with T2DM from two medical centers over a period of time. From January 2020 to 
      December 2022, 347 and 149 patients were recruited from the Beilun branch of 
      Zhejiang University's First Affiliated Hospital in the training and internal 
      validation cohorts, respectively. The external validation cohort consisted of 198 
      patients who were enrolled at Nanchang University's First Affiliated Hospital 
      from October 2020 to September 2021. We conducted univariate and multivariate 
      logistic regression analyses to select the risk factors for gastroparesis in 
      patients with T2DM; subsequently,we developed a nomogram model. The performance 
      of the nomogram was evaluated using the area under the receiver operating 
      characteristic (ROC) curve (AUC), calibration curve, and decision curve 
      analysis(DCA). RESULTS: Four clinical variables, including age, regular exercise, 
      glycated hemoglobin level(HbA1c), and Helicobacter pylori (H. pylori) infection, 
      were identified and included in the model. The model demonstrated excellent 
      discrimination, with an AUC of 0.951 (95% CI = 0.925-0.978) in the training 
      group, and 0.910 (95% CI = 0.859-0.961) and 0.875 (95% CI = 0.813-0.937) in the 
      internal and external validation groups, respectively. The calibration curve 
      showed good consistency between prediction of the model and observed 
      gastroparesis. The DCA also demonstrated good clinical efficacy. CONCLUSION: The 
      nomogram model developed in this study showed good performance in predicting 
      gastroparesis in patients with T2DM.
CI  - (c) 2024 The Authors. Published by Elsevier Ltd.
FAU - Yuan, Hai-Liang
AU  - Yuan HL
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, China.
AD  - The Precision Medicine Laboratory, Beilun Branch of the First Affiliated Hospital 
      of Zhejiang University, Ningbo, China.
FAU - Zhang, Xian
AU  - Zhang X
AD  - Department of Endocrinology, the First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Chu, Wei-Wei
AU  - Chu WW
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, China.
FAU - Lin, Guan-Bin
AU  - Lin GB
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, China.
FAU - Xu, Chun-Xia
AU  - Xu CX
AD  - Department of Gastroenterology, Beilun Branch of the First Affiliated Hospital of 
      Zhejiang University, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20240214
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10881375
OTO - NOTNLM
OT  - Gastroparesis
OT  - Model
OT  - Nomogram
OT  - Prediction
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/02/23 06:43
MHDA- 2024/02/23 06:44
PMCR- 2024/02/14
CRDT- 2024/02/23 03:52
PHST- 2023/11/12 00:00 [received]
PHST- 2024/02/06 00:00 [revised]
PHST- 2024/02/08 00:00 [accepted]
PHST- 2024/02/23 06:44 [medline]
PHST- 2024/02/23 06:43 [pubmed]
PHST- 2024/02/23 03:52 [entrez]
PHST- 2024/02/14 00:00 [pmc-release]
AID - S2405-8440(24)02252-7 [pii]
AID - e26221 [pii]
AID - 10.1016/j.heliyon.2024.e26221 [doi]
PST - epublish
SO  - Heliyon. 2024 Feb 14;10(4):e26221. doi: 10.1016/j.heliyon.2024.e26221. 
      eCollection 2024 Feb 29.