PMID- 38390376
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Print)
IS  - 1368-5031 (Linking)
VI  - 2024
DP  - 2024
TI  - Percutaneous Coronary Intervention with Procedural Unfractionated Heparin without 
      Activated Clotting Time Guidance: A Unique Opportunity to Assess Thrombotic and 
      Bleeding Events.
PG  - 6219301
LID - 10.1155/2024/6219301 [doi]
LID - 6219301
AB  - BACKGROUND: Rates of major bleeding and intraprocedural thrombotic events (IPTE) 
      in the setting of percutaneous coronary intervention (PCI) using weight-adjusted 
      unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are 
      not known. METHODS: We reviewed 2,748 consecutive patients who underwent coronary 
      angiography at our tertiary care university hospital between January 2017 and 
      December 2020. All patients who underwent PCI with weight-adjusted UFH without 
      ACT guidance were considered for further analysis. Major bleeding complications 
      occurring within 48 hours of PCI were collected from patients' medical records. 
      IPTE were collected independently by two interventional cardiologists after 
      review of coronary angiograms. RESULTS: There were 718 patients included in the 
      analysis (65.4 +/- 12.2 years old; 81.3% male). In total, 45 patients (7.8%) 
      experienced a major bleed or IPTE. The most common IPTE were slow/no reflow 
      (1.5%) and coronary artery dissection with decreased flow (1.1%). Other IPTE 
      occurred in <1% of cases. Major bleeding occurred in 11 patients (1.5%), of whom 
      8 required blood transfusion and 3 required vascular intervention. Bleeding 
      complications were more common with femoral compared with radial access (6.6% vs. 
      0.2%, P < 0.001). CONCLUSION: Weight-adjusted UFH use during PCI without ACT 
      monitoring was related to low rates of major bleeding or IPTE.
CI  - Copyright (c) 2024 Ali Z. Zgheib et al.
FAU - Zgheib, Ali Z
AU  - Zgheib AZ
AUID- ORCID: 0000-0002-6888-5429
AD  - American University of Beirut Medical Center, Division of Cardiology, Beirut, 
      Lebanon.
AD  - McGill University Health Centre, Division of Cardiology, Montreal, Canada.
FAU - Jdaidani, Jennifer
AU  - Jdaidani J
AD  - American University of Beirut Medical Center, Division of Cardiology, Beirut, 
      Lebanon.
FAU - Akl, Elie
AU  - Akl E
AD  - McGill University Health Centre, Division of Cardiology, Montreal, Canada.
FAU - Khalil, Suzan
AU  - Khalil S
AD  - University of California at Los Angeles, Division of Cardiology, Los Angeles, 
      California, USA.
FAU - Chaabo, Omar
AU  - Chaabo O
AD  - American University of Beirut Medical Center, Division of Cardiology, Beirut, 
      Lebanon.
AD  - McGill University Health Centre, Division of Cardiology, Montreal, Canada.
FAU - Piazza, Nicolo
AU  - Piazza N
AD  - McGill University Health Centre, Division of Cardiology, Montreal, Canada.
FAU - Sawaya, Fadi J
AU  - Sawaya FJ
AD  - American University of Beirut Medical Center, Division of Cardiology, Beirut, 
      Lebanon.
FAU - Rebeiz, Abdallah G
AU  - Rebeiz AG
AUID- ORCID: 0000-0002-2182-3298
AD  - American University of Beirut Medical Center, Division of Cardiology, Beirut, 
      Lebanon.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240215
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 9005-49-6 (Heparin)
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - Heparin/adverse effects
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Treatment Outcome
MH  - Hemorrhage/chemically induced
MH  - *Thrombosis
MH  - Anticoagulants/adverse effects
PMC - PMC10883739
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2024/02/23 06:42
MHDA- 2024/02/26 06:42
PMCR- 2024/02/15
CRDT- 2024/02/23 03:56
PHST- 2023/08/22 00:00 [received]
PHST- 2024/01/11 00:00 [revised]
PHST- 2024/02/07 00:00 [accepted]
PHST- 2024/02/26 06:42 [medline]
PHST- 2024/02/23 06:42 [pubmed]
PHST- 2024/02/23 03:56 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 10.1155/2024/6219301 [doi]
PST - epublish
SO  - Int J Clin Pract. 2024 Feb 15;2024:6219301. doi: 10.1155/2024/6219301. 
      eCollection 2024.