PMID- 38391039
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240325
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 64
IP  - 4
DP  - 2024 Apr
TI  - A novel therapeutic outlook: Classification, applications and challenges of 
      inhalable micron/nanoparticle drug delivery systems in lung cancer (Review).
LID - 38 [pii]
LID - 10.3892/ijo.2024.5626 [doi]
AB  - Lung cancer represents a marked global public health concern. Despite existing 
      treatment modalities, the average 5‑year survival rate for patients with patients 
      with lung cancer is only ~20%. As there are numerous adverse effects of systemic 
      administration routes, there is an urgent need to develop a novel therapeutic 
      strategy tailored specifically for patients with lung cancer. Non‑invasive 
      aerosol inhalation, as a route of drug administration, holds unique advantages in 
      the context of respiratory diseases. Nanoscale materials have extensive 
      applications in the field of biomedical research in recent years. The present 
      study provides a comprehensive review of the classification, applications 
      summarized according to existing clinical treatment modalities for lung cancer 
      and challenges associated with inhalable micron/nanoparticle drug delivery 
      systems (DDSs) in lung cancer. Achieving localized treatment of lung cancer 
      preclinical models through inhalation is deemed feasible. However, further 
      research is required to substantiate the efficacy and long‑term safety of 
      inhalable micron/nanoparticle DDSs in the clinical management of lung cancer.
FAU - Xie, Lixin
AU  - Xie L
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Xie, Daihan
AU  - Xie D
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Du, Zhefei
AU  - Du Z
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Xue, Shaobo
AU  - Xue S
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Wang, Kesheng
AU  - Wang K
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Yu, Xin
AU  - Yu X
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Liu, Xiuli
AU  - Liu X
AD  - Department of Medical Oncology, Affiliated Hospital of Guilin Medical University, 
      Guilin 541001, Guangxi Zhuang Autonomous Region, P.R. China.
FAU - Peng, Qiuxia
AU  - Peng Q
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
FAU - Fang, Chao
AU  - Fang C
AD  - Department of Medical Ultrasound and Central Laboratory of Shanghai Tenth 
      People's Hospital, Tongji University School of Medicine, Tongji University, 
      Shanghai 200072, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20240223
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Nanoparticle Drug Delivery System)
SB  - IM
MH  - Humans
MH  - Administration, Inhalation
MH  - Drug Delivery Systems
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Lung
MH  - *Lung Neoplasms/drug therapy
MH  - Nanoparticle Drug Delivery System
PMC - PMC10901537
OTO - NOTNLM
OT  - drug delivery system
OT  - inhalation
OT  - lung cancer
OT  - micron/nanoparticle
OT  - therapy
COIS- The authors declare that they have no competing interests.
EDAT- 2024/02/23 12:43
MHDA- 2024/02/26 06:42
PMCR- 2024/02/21
CRDT- 2024/02/23 08:05
PHST- 2023/10/13 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/02/26 06:42 [medline]
PHST- 2024/02/23 12:43 [pubmed]
PHST- 2024/02/23 08:05 [entrez]
PHST- 2024/02/21 00:00 [pmc-release]
AID - 38 [pii]
AID - ijo-64-04-05626 [pii]
AID - 10.3892/ijo.2024.5626 [doi]
PST - ppublish
SO  - Int J Oncol. 2024 Apr;64(4):38. doi: 10.3892/ijo.2024.5626. Epub 2024 Feb 23.