PMID- 38392838
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2076-0817 (Print)
IS  - 2076-0817 (Electronic)
IS  - 2076-0817 (Linking)
VI  - 13
IP  - 2
DP  - 2024 Jan 24
TI  - p16 Expression in Laryngeal Squamous Cell Carcinoma: A Surrogate or Independent 
      Prognostic Marker?
LID - 10.3390/pathogens13020100 [doi]
LID - 100
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common malignancy that, despite 
      scientific advancements, has not seen an improvement in its prognosis in the last 
      decades. Few promising predictive markers have been found and none are relevant 
      in clinical practice. p16(ink4a), an oncosuppressor protein involved in cell 
      cycle arrest, with a prognostic impact on other cancers, has been widely used in 
      the head and neck region as a surrogate marker of HPV infection. Published papers 
      and recent meta-analyses seem to minimize the biological role of HPV in the 
      context of LSCC's cancerogenesis, and to disprove the reliability of p16(ink4a) 
      as a surrogate prognostic marker in this context, while still highlighting its 
      potential role as an independent predictor of survival. Unfortunately, the 
      available literature, in particular during the last two decades, is often not 
      focused on its potential role as an independent biomarker and few relevant data 
      are found in papers mainly focused on HPV. The available data suggest that future 
      research should focus specifically on p16(ink4a), taking into account both its 
      potential inactivation and overexpression, different patterns of staining, and 
      immunohistochemistry cutoffs, and should focus not on its potential role as a 
      surrogate marker but on its independent role as a predictor of survival.
FAU - Gallus, Roberto
AU  - Gallus R
AUID- ORCID: 0000-0003-3343-2806
AD  - Otolaryngology, Mater Olbia Hospital, 07026 Olbia, Italy.
FAU - Rizzo, Davide
AU  - Rizzo D
AUID- ORCID: 0000-0003-1830-3731
AD  - U.O.C. Otorinolaringoiatria, Azienda Ospedaliero Universitaria di Sassari, Viale 
      San Pietro, 43, 07100 Sassari, Italy.
AD  - Otolaryngology Division, Department of Medicine, Surgery and Pharmacology, 
      University of Sassari, Viale San Pietro, 43, 07100 Sassari, Italy.
FAU - Rossi, Giorgia
AU  - Rossi G
AD  - Unit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" Hospital 
      Foundation IRCCS, 00168 Rome, Italy.
FAU - Mureddu, Luca
AU  - Mureddu L
AUID- ORCID: 0000-0002-2598-198X
AD  - U.O.C. Otorinolaringoiatria, Azienda Ospedaliero Universitaria di Sassari, Viale 
      San Pietro, 43, 07100 Sassari, Italy.
FAU - Galli, Jacopo
AU  - Galli J
AD  - Unit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" Hospital 
      Foundation IRCCS, 00168 Rome, Italy.
AD  - Department of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 
      00168 Rome, Italy.
FAU - Artuso, Alberto
AU  - Artuso A
AD  - Otolaryngology, Mater Olbia Hospital, 07026 Olbia, Italy.
FAU - Bussu, Francesco
AU  - Bussu F
AUID- ORCID: 0000-0001-6261-2772
AD  - U.O.C. Otorinolaringoiatria, Azienda Ospedaliero Universitaria di Sassari, Viale 
      San Pietro, 43, 07100 Sassari, Italy.
AD  - Otolaryngology Division, Department of Medicine, Surgery and Pharmacology, 
      University of Sassari, Viale San Pietro, 43, 07100 Sassari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240124
PL  - Switzerland
TA  - Pathogens
JT  - Pathogens (Basel, Switzerland)
JID - 101596317
PMC - PMC10892421
OTO - NOTNLM
OT  - HPV
OT  - LSCC
OT  - p16ink4a inactivation
OT  - p16ink4a overexpression
OT  - prognostic marker
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/23 12:43
MHDA- 2024/02/23 12:44
PMCR- 2024/01/24
CRDT- 2024/02/23 10:25
PHST- 2024/01/07 00:00 [received]
PHST- 2024/01/21 00:00 [revised]
PHST- 2024/01/22 00:00 [accepted]
PHST- 2024/02/23 12:44 [medline]
PHST- 2024/02/23 12:43 [pubmed]
PHST- 2024/02/23 10:25 [entrez]
PHST- 2024/01/24 00:00 [pmc-release]
AID - pathogens13020100 [pii]
AID - pathogens-13-00100 [pii]
AID - 10.3390/pathogens13020100 [doi]
PST - epublish
SO  - Pathogens. 2024 Jan 24;13(2):100. doi: 10.3390/pathogens13020100.