PMID- 38393049
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 22
IP  - 2
DP  - 2024 Feb 3
TI  - Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus 
      Spiromastix sp.
LID - 10.3390/md22020078 [doi]
LID - 78
AB  - Eleven new brominated depsidones, namely spiromastixones U-Z5 (1-11) along with 
      five known analogues (12-16), were isolated from a deep-sea-derived fungus 
      Spiromastix sp. through the addition of sodium bromide during fermentation. Their 
      structures were elucidated by extensive analysis of the spectroscopic data 
      including high-resolution MS and 1D and 2D NMR data. Compounds 6-10 and 16 
      exhibited significant inhibition against Gram-positive bacteria including 
      methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant 
      Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 muM. 
      Particularly, tribrominated 7 displayed the strongest activity against MRSA and 
      VRE with a MIC of 0.5 and 1.0 muM, respectively, suggesting its potential for 
      further development as a new antibacterial agent.
FAU - Huang, Zequan
AU  - Huang Z
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing 100191, China.
AD  - Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 
      530200, China.
FAU - Liu, Dong
AU  - Liu D
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Chen, Shang
AU  - Chen S
AUID- ORCID: 0000-0002-4874-2922
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Ren, Jinwei
AU  - Ren J
AD  - State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of 
      Sciences, Beijing 100101, China.
FAU - Gao, Chenghai
AU  - Gao C
AUID- ORCID: 0000-0002-7524-8049
AD  - Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 
      530200, China.
FAU - Li, Zhiyong
AU  - Li Z
AUID- ORCID: 0000-0001-9469-8857
AD  - State Key Laboratory of Microbial Metabolism, School of Life Sciences and 
      Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Fan, Aili
AU  - Fan A
AUID- ORCID: 0000-0003-4738-0517
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Lin, Wenhan
AU  - Lin W
AUID- ORCID: 0000-0002-4978-4083
AD  - State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical 
      Sciences, Peking University, Beijing 100191, China.
AD  - Ningbo Institute of Marine Medicine, Peking University, Ningbo 315832, China.
LA  - eng
GR  - 2022YFC2804500/the National Key Research and Development Project/
GR  - DY135-B-05/China Ocean Mineral Resource R&D Association/
GR  - 81991525, 82173733/National Natural Science Foundation of China/
GR  - 2022Z144, 2021Z046/the Ningbo Key Science and Technology Development Program/
GR  - MMLKF22-02/Open Funding Project of State Key Laboratory of Microbial Metabolism/
PT  - Journal Article
DEP - 20240203
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 3580-77-6 (depsidone)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Lactones)
RN  - 0 (Depsides)
SB  - IM
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Anti-Bacterial Agents/chemistry
MH  - Lactones/pharmacology
MH  - Fungi
MH  - Microbial Sensitivity Tests
MH  - *Depsides
PMC - PMC10890614
OTO - NOTNLM
OT  - Spiromastix sp.
OT  - antibacterial effects
OT  - brominated depsidone
OT  - fungus
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/23 12:43
MHDA- 2024/02/26 06:44
PMCR- 2024/02/03
CRDT- 2024/02/23 10:26
PHST- 2024/01/14 00:00 [received]
PHST- 2024/01/29 00:00 [revised]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/02/26 06:44 [medline]
PHST- 2024/02/23 12:43 [pubmed]
PHST- 2024/02/23 10:26 [entrez]
PHST- 2024/02/03 00:00 [pmc-release]
AID - md22020078 [pii]
AID - marinedrugs-22-00078 [pii]
AID - 10.3390/md22020078 [doi]
PST - epublish
SO  - Mar Drugs. 2024 Feb 3;22(2):78. doi: 10.3390/md22020078.