PMID- 38393211
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 12
IP  - 2
DP  - 2024 Jan 30
TI  - The Associations between Exposure to Multiple Heavy Metals and Total 
      Immunoglobulin E in U.S. Adults.
LID - 10.3390/toxics12020116 [doi]
LID - 116
AB  - Immunoglobulin E (IgE) is a type of immunoglobulin, and elevated serum total IgE 
      is often present in allergic diseases. Exposure to environmental heavy metals has 
      been markedly linked to allergic diseases, leading to elevated total IgE levels. 
      However, studies concerning the effects of multiple metal exposures on total IgE 
      levels are limited. Therefore, the current study seeks to explore the correlation 
      between heavy-metal co-exposure and total IgE levels based on the National Health 
      and Nutrition Examination Survey (NHANES, 2005-2006). Participants possessed 
      complete data on total IgE levels, 11 urinary metal concentrations and other 
      covariates. The correlations between 11 metals and total IgE levels were analyzed 
      using multiple linear regression, and total IgE levels were a continuous 
      variable. Total IgE levels exceeding 150 kU/L were considered sensitized. Binary 
      logistic regression analyses were employed to assess the correlation between 
      metal exposure and the occurrence of an allergic state. Then, the association 
      between co-exposure to the 11 metals and total IgE levels or the occurrence of 
      sensitization status was further analyzed by Bayesian kernel machine regression 
      (BKMR), a multi-contaminant model. There were 1429 adults with complete data 
      included. Based on the median concentration, molybdenum (Mo) had the highest 
      concentration (46.60 mug/L), followed by cesium (Cs), barium (Ba), lead (Pb), and 
      mercury (Hg). And the median (interquartile range) for total IgE levels was 43.7 
      (17.3, 126.0) kU/L. Multiple linear regression results showed that Pb was 
      significantly and positively associated with total IgE levels (beta = 0.165; 95% CI: 
      0.046, 0.284). Binary logistic regression showed a significant positive 
      correlation between urinary Pb (OR: 1.258; 95% CI: 1.052, 1.510) and tungsten (W) 
      (OR: 1.251; 95% CI: 1.082, 1.447). Importantly, the BKMR model found a positive 
      correlation between combined-metal exposure and total IgE levels and the 
      occurrence of sensitization status. The mixed heavy-metal exposure was associated 
      with increased total IgE levels, and this association may be driven primarily by 
      the exposure of Pb and W. This study provides new insights into the relationship 
      between heavy-metal exposure and allergic diseases. More research is needed to 
      confirm these findings.
FAU - Song, Xin
AU  - Song X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, Beijing 100069, China.
AD  - Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, 
      Beijing 100069, China.
FAU - Ding, Xiaowen
AU  - Ding X
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 
      100093, China.
FAU - Niu, Piye
AU  - Niu P
AUID- ORCID: 0000-0002-0155-3438
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, Beijing 100069, China.
AD  - Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, 
      Beijing 100069, China.
FAU - Chen, Tian
AU  - Chen T
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, Beijing 100069, China.
AD  - Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, 
      Beijing 100069, China.
FAU - Yan, Tenglong
AU  - Yan T
AUID- ORCID: 0000-0002-2424-0223
AD  - Beijing Institute of Occupational Disease Prevention and Treatment, Beijing 
      100093, China.
LA  - eng
GR  - 7234402/Beijing Natural Science Foundation/
PT  - Journal Article
DEP - 20240130
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC10891582
OTO - NOTNLM
OT  - BKMR
OT  - heavy metals
OT  - mixture
OT  - total immunoglobulin E (total IgE)
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/23 12:42
MHDA- 2024/02/23 12:43
PMCR- 2024/01/30
CRDT- 2024/02/23 10:34
PHST- 2023/12/28 00:00 [received]
PHST- 2024/01/25 00:00 [revised]
PHST- 2024/01/27 00:00 [accepted]
PHST- 2024/02/23 12:43 [medline]
PHST- 2024/02/23 12:42 [pubmed]
PHST- 2024/02/23 10:34 [entrez]
PHST- 2024/01/30 00:00 [pmc-release]
AID - toxics12020116 [pii]
AID - toxics-12-00116 [pii]
AID - 10.3390/toxics12020116 [doi]
PST - epublish
SO  - Toxics. 2024 Jan 30;12(2):116. doi: 10.3390/toxics12020116.