PMID- 38393508
OWN - NLM
STAT- Publisher
LR  - 20240223
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
DP  - 2024 Feb 23
TI  - Association between thyroid autoimmunity and bone mineral density in patients 
      with type 2 diabetes mellitus: a cross-sectional study.
LID - 10.1007/s12020-024-03733-3 [doi]
AB  - PURPOSE: The purpose of this study was to analyze the relationship between 
      thyroid autoimmunity and bone mineral density (BMD) in patients with type 2 
      diabetes mellitus (T2DM), and to further explore the influence of thyroid 
      autoimmunity on diabetic osteoporosis. METHODS: A total of 601 T2DM patients were 
      included and divided into two groups according to thyroid autoantibodies, namely 
      thyroid autoimmunity positive group (TPOAb+ or TGAb + ) and thyroid autoimmunity 
      negative group (TPOAb- and TGAb-). Clinical data were collected and BMD was 
      determined by dual-energy X-ray absorptiometry (DXA). SPSS26.0 software was used 
      to data analysis. Model regression was used to analyze the influencing factors of 
      BMD, and ROC curve was used to analyze the optimal cut-off point of thyroid 
      peroxidase antibody (TPOAb) for screening osteoporosis. RESULTS: TPOAb and 
      thyroglobulin antibody (TGAb) were negatively correlated with BMD and T-score 
      (LS, FN and WB) (P < 0.01), and TGAb was negatively correlated with 25(OH)D 
      (P < 0.05). Multiple linear regression analysis showed that TPOAb was an 
      independent influence factor on LS, FN and WB BMD. ROC curve analysis showed that 
      the optimal threshold of TPOAb for predicting osteoporosis was 12.35. 
      CONCLUSIONS: In T2DM patients, TPOAb and TGAb levels are negatively correlated 
      with LS, FN and WB BMD, and TPOAb is an independent influencing factor for 
      diabetic osteoporosis, and TPOAb has a certain predictive value for the 
      occurrence and development of diabetic osteoporosis clinically.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Wang, Zhen
AU  - Wang Z
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Bai, Jia
AU  - Bai J
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Zou, Jingyi
AU  - Zou J
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Yuan, Yue
AU  - Yuan Y
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Li, Shuyun
AU  - Li S
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Wang, Mengke
AU  - Wang M
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China.
FAU - Lv, Haihong
AU  - Lv H
AUID- ORCID: 0000-0003-2073-4899
AD  - The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, 
      Gansu, PR China. haihonglv@126.com.
AD  - Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, 
      730000, Gansu, PR China. haihonglv@126.com.
LA  - eng
GR  - No. 2021JSCX0011/the Science and Technology Planning Project of Lanzhou Chengguan 
      District/
GR  - No. 2021JSCX0011/the Science and Technology Planning Project of Lanzhou Chengguan 
      District/
GR  - No. 23JRRA1499/Natural Science Foundation of Gansu Province/
PT  - Journal Article
DEP - 20240223
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
OTO - NOTNLM
OT  - Bone mineral density
OT  - Osteoporosis
OT  - Thyroid autoimmunity
OT  - Type 2 diabetes mellitus
EDAT- 2024/02/23 12:43
MHDA- 2024/02/23 12:43
CRDT- 2024/02/23 11:15
PHST- 2023/09/22 00:00 [received]
PHST- 2024/02/07 00:00 [accepted]
PHST- 2024/02/23 12:43 [medline]
PHST- 2024/02/23 12:43 [pubmed]
PHST- 2024/02/23 11:15 [entrez]
AID - 10.1007/s12020-024-03733-3 [pii]
AID - 10.1007/s12020-024-03733-3 [doi]
PST - aheadofprint
SO  - Endocrine. 2024 Feb 23. doi: 10.1007/s12020-024-03733-3.