PMID- 38393530
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240403
IS  - 2523-899X (Electronic)
IS  - 2523-899X (Linking)
VI  - 44
IP  - 1
DP  - 2024 Feb
TI  - Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by 
      Suppressing the TNF-alpha/NF-kappaB Signaling Pathway.
PG  - 232-240
LID - 10.1007/s11596-024-2828-8 [doi]
AB  - OBJECTIVE: Secoemestrin C (SC), an epitetrathiodioxopiperazine isolated from 
      Aspergillus nidulans, has been previously reported to have immunomodulatory and 
      hepatoprotective effects against acute autoimmune hepatitis. However, the effect 
      of SC on regulating the inflammation and its underlying mechanisms in the 
      pathogenesis of psoriasis remain unclear. This study aimed to evaluate the 
      effects of SC on inflammatory dermatosis both in vitro and in vivo. METHODS: In 
      vitro, HaCaT cells were induced with tumor necrosis factor-alpha (TNF-alpha, 10 
      ng/mL) to establish an inflammatory injury model, and the expression of nuclear 
      transcription factor-kappaB (NF-kappaB) pathway components was measured using qRT-PCR and 
      Western blotting. An in vivo mouse model of imiquimod (IMQ)-induced 
      psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in 
      alleviating psoriasis. RESULTS: SC significantly blocked the activation of NF-kappaB 
      signaling in TNF-alpha-stimulated HaCaT cells. In addition, systemic and local 
      administration of SC improved psoriatic dermatitis in the IMQ-induced mouse 
      model. SC reduced skin scale and significantly inhibited the secretion of 
      inflammatory factors in skin lesions. CONCLUSION: The protective effect of SC 
      against psoriatic-associated inflammation reveals its potential therapeutic value 
      for treating psoriasis.
CI  - (c) 2024. Huazhong University of Science and Technology.
FAU - Zhu, Zhi-Bin
AU  - Zhu ZB
AD  - Department of Stomatology, Chengdu Seventh People's Hospital, Chengdu, 610044, 
      China.
FAU - Liu, Meng-Jie
AU  - Liu MJ
AD  - Department of Stomatology, Chengdu Seventh People's Hospital, Chengdu, 610044, 
      China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Shu, Zhou
AU  - Shu Z
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Cao, Jie
AU  - Cao J
AD  - Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. 
      ouyangdielong@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240223
PL  - China
TA  - Curr Med Sci
JT  - Current medical science
JID - 101729993
RN  - P1QW714R7M (Imiquimod)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Dermatitis/complications/drug therapy
MH  - Imiquimod/adverse effects
MH  - Inflammation/drug therapy/chemically induced
MH  - NF-kappa B/metabolism
MH  - *Psoriasis/chemically induced/drug therapy/genetics
MH  - *Signal Transduction
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - inflammation
OT  - nuclear transcription factor-kappaB (NF-kappaB)
OT  - psoriasis
OT  - secoemestrin C (SC)
OT  - tumor necrosis factor-alpha (TNF-alpha)
EDAT- 2024/02/23 12:42
MHDA- 2024/02/26 06:42
CRDT- 2024/02/23 11:16
PHST- 2023/03/17 00:00 [received]
PHST- 2023/12/03 00:00 [accepted]
PHST- 2024/02/26 06:42 [medline]
PHST- 2024/02/23 12:42 [pubmed]
PHST- 2024/02/23 11:16 [entrez]
AID - 10.1007/s11596-024-2828-8 [pii]
AID - 10.1007/s11596-024-2828-8 [doi]
PST - ppublish
SO  - Curr Med Sci. 2024 Feb;44(1):232-240. doi: 10.1007/s11596-024-2828-8. Epub 2024 
      Feb 23.