PMID- 38394514
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 103
IP  - 8
DP  - 2024 Feb 23
TI  - Evaluation of short-term adverse events of COVID-19 vaccines: An observational 
      study.
PG  - e35549
LID - 10.1097/MD.0000000000035549 [doi]
AB  - Coronavirus disease 2019 (COVID-19) vaccines are the most effective tools in 
      managing the pandemic. However, the concern about these vaccines is the 
      occurrence of unwanted adverse events (AEs). This study aimed to evaluate the 
      short-term AEs of COVID-19 vaccines (Sputnik V, Astrazenka, and Sinopharm). A 
      cross-sectional study using an online questionnaire was conducted among 321 
      vaccinated individuals. Demographic information, history of drug use, prior 
      infection with COVID-19, the type of vaccine, vaccination stage, local injection 
      site complication, systemic complication, and allergic reactions were collected 
      and evaluated. Local complications, including pain and swelling at the injection 
      site, and systemic complications, including fever, fatigue, lethargy, 
      lymphadenopathy, and diarrhea, were reported after the injection of the 
      AstraZeneca vaccine was more than the other 2 vaccines; The prevalence of fatigue 
      and lethargy was higher than other systemic complications. The least reported 
      complication was due to lymphadenopathy. The Sinopharm vaccine showed a lower 
      prevalence of AEs than the other 2. The rare AEs, such as facial paralysis, nasal 
      bleeding, and urticarial, were further reported after injection of the 
      AstraZeneca vaccine. In general, the severity of systemic complications after the 
      second dose of the vaccine was also higher than the first dose. All 3 vaccines 
      were safe and tolerable. The most commonly reported AEs were injection site pain 
      (local) and fatigue and lethargy (systemic). These expected AEs occurred shortly 
      after vaccination and indicated an early immune response after vaccination.
CI  - Copyright (c) 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Fathi, Fatemeh
AU  - Fathi F
AD  - Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Ameri, Ali
AU  - Ameri A
AD  - Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Safa, Omid
AU  - Safa O
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Hormozgan University of 
      Medical Sciences, Bandar Abbas, Iran.
FAU - Hassaniazad, Mehdi
AU  - Hassaniazad M
AD  - Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, 
      Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
FAU - Fathalipour, Mohammad
AU  - Fathalipour M
AUID- ORCID: 0000-0002-4568-7024
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hormozgan 
      University of Medical Sciences, Bandar Abbas, Iran.
AD  - Department of Endocrinology and Metabolic Research Center, Hormozgan University 
      of Medical Sciences, Bandar Abbas, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Vaccines)
SB  - IM
MH  - Humans
MH  - COVID-19 Vaccines/adverse effects
MH  - Lethargy
MH  - Cross-Sectional Studies
MH  - *COVID-19/epidemiology/prevention & control
MH  - Fatigue/epidemiology/etiology
MH  - *Lymphadenopathy
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Pain
MH  - *Vaccines
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2024/02/23 18:42
MHDA- 2024/02/26 06:43
CRDT- 2024/02/23 16:03
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/23 18:42 [pubmed]
PHST- 2024/02/23 16:03 [entrez]
AID - 00005792-202402230-00033 [pii]
AID - 10.1097/MD.0000000000035549 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2024 Feb 23;103(8):e35549. doi: 
      10.1097/MD.0000000000035549.