PMID- 38395015
OWN - NLM
STAT- MEDLINE
DCOM- 20240312
LR  - 20240312
IS  - 1873-622X (Electronic)
IS  - 0005-7967 (Linking)
VI  - 175
DP  - 2024 Apr
TI  - Mindfulness-induced self-transcendence promotes universal love with consequent 
      effects on opioid misuse.
PG  - 104494
LID - S0005-7967(24)00021-4 [pii]
LID - 10.1016/j.brat.2024.104494 [doi]
AB  - In addition to its health benefits, mindfulness has been theorized in classical 
      contemplative frameworks to elicit self-transcendent experiences as a means of 
      promoting universal love and compassion. Increasing feelings of love may be 
      especially clinically relevant for the treatment of opioid misuse, in that 
      addictive use of opioids dysregulates neurobiological processes implicated in the 
      experience of love. Here we tested these hypotheses in a secondary analysis 
      (n = 187) of data from a randomized clinical trial of Mindfulness-Oriented 
      Recovery Enhancement (MORE) versus supportive psychotherapy for comorbid opioid 
      misuse and chronic pain. At pre- and post-treatment, participants completed a 
      measure of state self-transcendence immediately following a laboratory-based 
      mindfulness task. Through 9-month follow-up, we assessed changes in universal 
      love and opioid misuse. Participants also completed ecological momentary 
      assessments of opioid craving during the 8-week study interventions and for the 
      following month. Compared to supportive psychotherapy, participants in MORE 
      reported significantly greater increases in mindfulness-induced 
      self-transcendence, which mediated the effect of MORE on increased feelings of 
      universal love. In turn, increases in universal love significantly predicted 
      decreased opioid craving and lower odds opioid misuse through 1- and 9-month 
      follow-ups, respectively. Findings suggest mindfulness-induced self-transcendence 
      may promote feelings of universal love, with possible downstream benefits on 
      reducing addictive behavior.
CI  - Copyright (c) 2024. Published by Elsevier Ltd.
FAU - Garland, Eric L
AU  - Garland EL
AD  - Center on Mindfulness and Integrative Health Intervention Development, University 
      of Utah, USA. Electronic address: eric.garland@socwk.utah.edu.
FAU - Jinpa, Thupten
AU  - Jinpa T
AD  - School of Religious Studies, McGill University, Canada.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20240207
PL  - England
TA  - Behav Res Ther
JT  - Behaviour research and therapy
JID - 0372477
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Humans
MH  - Analgesics, Opioid/therapeutic use
MH  - Love
MH  - *Mindfulness
MH  - *Opioid-Related Disorders/complications/drug therapy
MH  - Emotions
MH  - *Chronic Pain/therapy
OTO - NOTNLM
OT  - Addiction
OT  - Compassion
OT  - Love
OT  - Nondual awareness
OT  - Opioid use disorder
COIS- Declaration of competing interest Eric Garland is the Director of the Center on 
      Mindfulness and Integrative Health Intervention Development. The Center provides 
      Mindfulness-Oriented Recovery Enhancement (MORE), mindfulness-based therapy, and 
      cognitive behavioral therapy in the context of research trials for no cost to 
      research participants; however, Dr. Garland has received honoraria and payment 
      for delivering seminars, lectures, and teaching engagements (related to training 
      clinicians in mindfulness) sponsored by institutions of higher education, 
      government agencies, academic teaching hospitals, and medical centers. Dr. 
      Garland also receives royalties from the sale of books related to MORE. Dr. 
      Garland is a licensor to BehaVR, LLC. Thupten Jinpa is the founder and President 
      of the Compassion Institute and the principal author of Compassion Cultivation 
      Training.
EDAT- 2024/02/24 11:42
MHDA- 2024/03/12 06:43
CRDT- 2024/02/23 18:13
PHST- 2023/09/19 00:00 [received]
PHST- 2024/02/01 00:00 [revised]
PHST- 2024/02/06 00:00 [accepted]
PHST- 2024/03/12 06:43 [medline]
PHST- 2024/02/24 11:42 [pubmed]
PHST- 2024/02/23 18:13 [entrez]
AID - S0005-7967(24)00021-4 [pii]
AID - 10.1016/j.brat.2024.104494 [doi]
PST - ppublish
SO  - Behav Res Ther. 2024 Apr;175:104494. doi: 10.1016/j.brat.2024.104494. Epub 2024 
      Feb 7.