PMID- 38395955
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2057-3804 (Electronic)
IS  - 2057-3804 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Feb 23
TI  - The efficacy and safety of exercise regimens to mitigate chemotherapy 
      cardiotoxicity: a systematic review and meta-analysis of randomized controlled 
      trials.
PG  - 10
LID - 10.1186/s40959-024-00208-2 [doi]
LID - 10
AB  - BACKGROUND: Cardiotoxicity is one of the most common adverse events of the 
      chemotherapy. Physical exercise was shown to be cardioprotective. We aim to 
      estimate the efficacy and safety of exercise in cancer patients receiving 
      cardiotoxic chemotherapy. METHODS: We conducted a systematic review and 
      meta-analysis of randomized controlled trials (RCTs), which were retrieved by 
      systematically searching PubMed, Web of Science, SCOPUS, Cochrane, Clinical 
      Trials.gov, and MedRxiv through July 17th, 2023. We used RevMan V. 5.4 to pool 
      dichotomous data using risk ratio (RR) and continuous data using mean difference 
      (MD), with a 95% confidence interval (CI). PROSPERO ID: CRD42023460902. RESULTS: 
      We included thirteen RCTs with a total of 952 patients. Exercise significantly 
      increased VO(2) peak (MD: 1.95 with 95% CI [0.59, 3.32], P = 0.005). However, 
      there was no significant effect regarding left ventricular ejection fraction, 
      global longitudinal strain, cardiac output, stroke volume, left ventricular 
      end-diastolic volume, left ventricular end-systolic volume, E/A ratio, resting 
      heart rate, peak heart rate, resting systolic blood pressure, and resting 
      diastolic blood pressure. Also, there was no significant difference regarding any 
      adverse events (AEs) (RR: 4.44 with 95% CI [0.47, 41.56], P = 0.19), AEs leading 
      to withdrawal (RR: 2.87 with 95% CI [0.79, 10.43], P = 0.11), serious AEs (RR: 
      3.00 with 95% CI [0.14, 65.90], P = 0.49), or all-cause mortality (RR: 0.25 with 
      95% CI [0.03, 2.22], P = 0.21). CONCLUSION: Exercise is associated with increased 
      VO(2) peak in cancer patients receiving cardiotoxic chemotherapy. However, there 
      was no significant difference between exercise and usual care regarding the 
      echocardiographic and safety outcomes.
CI  - (c) 2024. The Author(s).
FAU - Amin, Ahmed Mazen
AU  - Amin AM
AD  - Faculty of Medicine, Mansoura University, Mansoura, Egypt. 
      ahmedmazenaliamin@gmail.com.
FAU - Khlidj, Yehya
AU  - Khlidj Y
AD  - Faculty of Medicine, Algiers University, Algiers, Algeria.
FAU - Abuelazm, Mohamed
AU  - Abuelazm M
AD  - Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Ibrahim, Ahmed A
AU  - Ibrahim AA
AD  - Faculty of Medicine, Menoufia University, Menoufia, Egypt.
FAU - Tanashat, Mohammad
AU  - Tanashat M
AD  - Faculty of Medicine, Yarmouk University, Irbid, Jordan.
FAU - Imran, Muhammad
AU  - Imran M
AD  - University College of Medicine and Dentistry, The University of Lahore, Lahore, 
      Pakistan.
FAU - Nazir, Abubakar
AU  - Nazir A
AD  - Faculty of Medicine, King Edward Medical University, Lahore, Pakistan.
FAU - Shaikhkhalil, Hosam
AU  - Shaikhkhalil H
AD  - Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine.
FAU - Abdelazeem, Basel
AU  - Abdelazeem B
AD  - Department of Cardiology, West Virginia University, Morgantown, WV, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240223
PL  - England
TA  - Cardiooncology
JT  - Cardio-oncology (London, England)
JID - 101689938
PMC - PMC10885653
OTO - NOTNLM
OT  - Cancer
OT  - Cardiotoxic
OT  - Chemotherapy
OT  - Exercise
OT  - Meta-analysis
OT  - Review
COIS- The authors declare no competing interests.
EDAT- 2024/02/24 11:42
MHDA- 2024/02/24 11:43
PMCR- 2024/02/23
CRDT- 2024/02/23 23:44
PHST- 2023/10/05 00:00 [received]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/02/24 11:43 [medline]
PHST- 2024/02/24 11:42 [pubmed]
PHST- 2024/02/23 23:44 [entrez]
PHST- 2024/02/23 00:00 [pmc-release]
AID - 10.1186/s40959-024-00208-2 [pii]
AID - 208 [pii]
AID - 10.1186/s40959-024-00208-2 [doi]
PST - epublish
SO  - Cardiooncology. 2024 Feb 23;10(1):10. doi: 10.1186/s40959-024-00208-2.