PMID- 38396081
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240227
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 23
TI  - Motivation levels and white matter microstructure in children living with HIV.
PG  - 4425
LID - 10.1038/s41598-024-54411-3 [doi]
LID - 4425
AB  - Central nervous system involvement in HIV infection leads to neurobehavioural 
      sequelae. Although apathy is a well-recognised symptom in adults living with HIV 
      linked to alterations in brain structure, there is scarce research examining 
      motivation in children living with HIV (CLWH). We used the Children's Motivation 
      Scale (CMS; normative mean = 50, SD = 10) to assess motivation levels in 76 CLWH 
      aged 6-16 years (63 on antiretroviral therapy [ART]; 13 ART-naive slow 
      progressors) in South Africa. Overall, CLWH scored low on the CMS (mean = 35.70 
      [SD = 5.87]). Motivation levels were significantly reduced in children taking ART 
      compared to ART-naive slow progressors (p = 0.02), but were not correlated with 
      markers of HIV disease (CD4 + cell count or viral load), or neurocognitive 
      function (p > 0.05). CMS scores were correlated with diffusion tensor imaging 
      metrics of white matter microstructure in specific frontostriatal brain regions 
      (p < 0.05). On multiple regression, associations with the anterior limb of the 
      internal capsule, a subcortical white matter region, remained significant after 
      adjusting for potential confounders. These findings suggest that reduced 
      motivation may be an important neurobehavioural symptom in CLWH and may reflect 
      changes in white matter microstructure of frontostriatal brain regions.
CI  - (c) 2024. The Author(s).
FAU - Wedderburn, Catherine J
AU  - Wedderburn CJ
AD  - Department of Paediatrics and Child Health, University of Cape Town, Cape Town, 
      South Africa. catherine.wedderburn@lshtm.ac.uk.
AD  - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. 
      catherine.wedderburn@lshtm.ac.uk.
AD  - Department of Clinical Research, London School of Hygiene and Tropical Medicine, 
      London, UK. catherine.wedderburn@lshtm.ac.uk.
FAU - Sevenoaks, Tatum
AU  - Sevenoaks T
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Fouche, Jean-Paul
AU  - Fouche JP
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Phillips, Nicole J
AU  - Phillips NJ
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
FAU - Lawn, Stephen D
AU  - Lawn SD
AD  - Department of Clinical Research, London School of Hygiene and Tropical Medicine, 
      London, UK.
FAU - Stein, Dan J
AU  - Stein DJ
AD  - Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
AD  - SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, 
      Cape Town, South Africa.
FAU - Hoare, Jacqueline
AU  - Hoare J
AD  - Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
AD  - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, 
      South Africa.
LA  - eng
GR  - 203525/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20240223
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Child
MH  - Adult
MH  - Humans
MH  - *White Matter
MH  - *HIV Infections/complications/drug therapy
MH  - Diffusion Tensor Imaging
MH  - Motivation
MH  - Brain/diagnostic imaging
PMC - PMC10891087
OTO - NOTNLM
OT  - Apathy
OT  - Children
OT  - Diffusion tensor imaging
OT  - HIV
OT  - Motivation
COIS- The authors declare no competing interests.
EDAT- 2024/02/24 11:44
MHDA- 2024/02/26 06:45
PMCR- 2024/02/23
CRDT- 2024/02/23 23:53
PHST- 2023/06/04 00:00 [received]
PHST- 2024/02/12 00:00 [accepted]
PHST- 2024/02/26 06:45 [medline]
PHST- 2024/02/24 11:44 [pubmed]
PHST- 2024/02/23 23:53 [entrez]
PHST- 2024/02/23 00:00 [pmc-release]
AID - 10.1038/s41598-024-54411-3 [pii]
AID - 54411 [pii]
AID - 10.1038/s41598-024-54411-3 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 23;14(1):4425. doi: 10.1038/s41598-024-54411-3.