PMID- 38396489
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 14
IP  - 4
DP  - 2024 Feb 19
TI  - Monocyte Chemoattractant Protein-1 (MCP-1), Activin-A and Clusterin in Children 
      and Adolescents with Obesity or Type-1 Diabetes Mellitus.
LID - 10.3390/diagnostics14040450 [doi]
LID - 450
AB  - Inflammation plays a crucial role in diabetes and obesity through macrophage 
      activation. Macrophage chemoattractant protein-1 (MCP-1), activin-A, and 
      clusterin are chemokines with known roles in diabetes and obesity. The aim of 
      this study is to investigate their possible diagnostic and/or early prognostic 
      values in children and adolescents with obesity and type-1 diabetes mellitus 
      (T1DM). METHODS: We obtained serum samples from children and adolescents with a 
      history of T1DM or obesity, in order to measure and compare MCP-1, activin-A, and 
      clusterin concentrations. RESULTS: Forty-three subjects were included in each of 
      the three groups (controls, T1DM, and obesity). MCP-1 values were positively 
      correlated to BMI z-score. Activin-A was increased in children with obesity 
      compared to the control group. A trend for higher values was detected in children 
      with T1DM. MCP-1 and activin-A levels were positively correlated. Clusterin 
      levels showed a trend towards lower values in children with T1DM or obesity 
      compared to the control group and were negatively correlated to renal function. 
      CONCLUSIONS: The inflammation markers MCP-1, activin-A, and clusterin are not 
      altered in children with T1DM. Conversely, obesity in children is positively 
      correlated to serum MCP-1 values and characterized by higher activin-A levels, 
      which may reflect an already established systematic inflammation with obesity 
      since childhood.
FAU - Kostopoulou, Eirini
AU  - Kostopoulou E
AUID- ORCID: 0000-0002-7051-7537
AD  - Division of Pediatric Endocrinology, Department of Pediatrics, University 
      Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, 
      Greece.
FAU - Kalavrizioti, Dimitra
AU  - Kalavrizioti D
AD  - Department of Nephrology and Kidney Transplantation, University Hospital of 
      Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
FAU - Davoulou, Panagiota
AU  - Davoulou P
AD  - Department of Nephrology and Kidney Transplantation, University Hospital of 
      Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
FAU - Papachristou, Evangelos
AU  - Papachristou E
AD  - Department of Nephrology and Kidney Transplantation, University Hospital of 
      Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
FAU - Sinopidis, Xenophon
AU  - Sinopidis X
AUID- ORCID: 0000-0002-0878-0668
AD  - Department of Pediatric Surgery, University Hospital of Patras, School of 
      Medicine, University of Patras, 26504 Patras, Greece.
FAU - Fouzas, Sotirios
AU  - Fouzas S
AUID- ORCID: 0000-0001-7617-9076
AD  - Department of Pediatrics, University Hospital of Patras, School of Medicine, 
      University of Patras, 26504 Patras, Greece.
FAU - Dassios, Theodore
AU  - Dassios T
AD  - Department of Pediatrics, University Hospital of Patras, School of Medicine, 
      University of Patras, 26504 Patras, Greece.
FAU - Gkentzi, Despoina
AU  - Gkentzi D
AD  - Department of Pediatrics, University Hospital of Patras, School of Medicine, 
      University of Patras, 26504 Patras, Greece.
FAU - Kyriakou, Stavroula Ioanna
AU  - Kyriakou SI
AD  - Department of Pediatric Surgery, University Hospital of Patras, School of 
      Medicine, University of Patras, 26504 Patras, Greece.
FAU - Karatza, Ageliki
AU  - Karatza A
AD  - Department of Pediatrics, University Hospital of Patras, School of Medicine, 
      University of Patras, 26504 Patras, Greece.
FAU - Dimitriou, Gabriel
AU  - Dimitriou G
AD  - Department of Pediatrics, University Hospital of Patras, School of Medicine, 
      University of Patras, 26504 Patras, Greece.
FAU - Goumenos, Dimitrios
AU  - Goumenos D
AD  - Department of Nephrology and Kidney Transplantation, University Hospital of 
      Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
FAU - Spiliotis, Bessie E
AU  - Spiliotis BE
AUID- ORCID: 0000-0001-7922-4012
AD  - Division of Pediatric Endocrinology, Department of Pediatrics, University 
      Hospital of Patras, School of Medicine, University of Patras, 26504 Patras, 
      Greece.
FAU - Plotas, Panagiotis
AU  - Plotas P
AUID- ORCID: 0000-0001-5514-7083
AD  - Department of Speech and Language Therapy, School of Health Rehabilitation 
      Sciences, University of Patras, 26504 Patras, Greece.
FAU - Papasotiriou, Marios
AU  - Papasotiriou M
AUID- ORCID: 0000-0001-9375-989X
AD  - Department of Nephrology and Kidney Transplantation, University Hospital of 
      Patras, School of Medicine, University of Patras, 26504 Patras, Greece.
LA  - eng
PT  - Journal Article
DEP - 20240219
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10887959
OTO - NOTNLM
OT  - activin-A
OT  - adolescents
OT  - children
OT  - clusterin
OT  - diagnosis
OT  - monocyte chemoattractant protein-1 (MCP-1)
OT  - obesity
OT  - prognosis
OT  - type-1 diabetes mellitus (T1DM)
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/24 11:45
MHDA- 2024/02/24 11:46
PMCR- 2024/02/19
CRDT- 2024/02/24 01:01
PHST- 2023/12/09 00:00 [received]
PHST- 2024/02/04 00:00 [revised]
PHST- 2024/02/17 00:00 [accepted]
PHST- 2024/02/24 11:46 [medline]
PHST- 2024/02/24 11:45 [pubmed]
PHST- 2024/02/24 01:01 [entrez]
PHST- 2024/02/19 00:00 [pmc-release]
AID - diagnostics14040450 [pii]
AID - diagnostics-14-00450 [pii]
AID - 10.3390/diagnostics14040450 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2024 Feb 19;14(4):450. doi: 10.3390/diagnostics14040450.