PMID- 38396513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 14
IP  - 4
DP  - 2024 Feb 6
TI  - Pilot Study on the Efficacy and Safety of Long-Term Oral Imepitoin Treatment for 
      Control of (Thunder)Storm-Associated Noise Phobia/Noise Aversion in Dogs Using an 
      Individualized-Dose Titration Approach.
LID - 10.3390/ani14040545 [doi]
LID - 545
AB  - Imepitoin is a low-affinity partial agonist for benzodiazepine binding sites of 
      gamma-aminobutyric acid receptors with anxiolytic effects. It has been shown to 
      reduce anxiety during noise-related events in dogs when given at 30 mg/kg PO BID, 
      although this dose was associated with ataxia and increased appetite in some 
      cases. The objective of this study was to assess its safety and efficacy for 
      storm anxiety when started at 10 mg/kg PO BID and titrated to effect up to 30 
      mg/kg PO BID during storm season. Significant decreases in anxiety scores were 
      seen in weekly surveys and storm logs (SLs) at 10, 20 and 30 mg/kg PO BID. 
      Serious adverse events (AEs) were not reported in any subject. Ataxia was the 
      most commonly reported non-serious AE (14/33), followed by increased hunger 
      (13/33). The frequency of AEs was higher in the 20 mg/kg PO BID group than in the 
      10 mg/kg group PO BID. No clinically significant changes were seen in lab work 
      pre- and post-study. In conclusion, Imepitoin given during storm season at doses 
      ranging from 10 to 30 mg/kg PO BID reduced clinical signs of fear and anxiety 
      during storms for the dogs in this study. These findings support the use of an 
      individually titrated dose.
FAU - Munoz Amezcua, Ana C
AU  - Munoz Amezcua AC
AD  - Department of Clinical Sciences, College of Veterinary Medicine, North Carolina 
      State University, Raleigh, NC 27606, USA.
FAU - Jones, Jennifer M
AU  - Jones JM
AD  - Department of Clinical Sciences, College of Veterinary Medicine, North Carolina 
      State University, Raleigh, NC 27606, USA.
FAU - Griffith, Emily H
AU  - Griffith EH
AD  - Department of Statistics, North Carolina State University, Raleigh, NC 27606, 
      USA.
FAU - Gruen, Margaret E
AU  - Gruen ME
AD  - Department of Clinical Sciences, College of Veterinary Medicine, North Carolina 
      State University, Raleigh, NC 27606, USA.
LA  - eng
GR  - 543798/Boehringer Ingelheim Vetmedica GmbH/
PT  - Journal Article
DEP - 20240206
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC10886229
OTO - NOTNLM
OT  - antiepileptic
OT  - anxiety
OT  - anxiolytic
OT  - clinical trial
OT  - imepitoin
OT  - noise
OT  - phobia
OT  - storm
COIS- Margaret Gruen has served as a consultant and sponsored speaker for Boehringer 
      Ingelheim. The remaining authors declare they have no conflicts of interest. 
      Boehringer Ingelheim Vetmedica GmbH was involved in the design of the study but 
      not in the analysis or reporting of the study.
EDAT- 2024/02/24 11:44
MHDA- 2024/02/24 11:45
PMCR- 2024/02/06
CRDT- 2024/02/24 01:01
PHST- 2023/12/21 00:00 [received]
PHST- 2024/01/17 00:00 [revised]
PHST- 2024/01/25 00:00 [accepted]
PHST- 2024/02/24 11:45 [medline]
PHST- 2024/02/24 11:44 [pubmed]
PHST- 2024/02/24 01:01 [entrez]
PHST- 2024/02/06 00:00 [pmc-release]
AID - ani14040545 [pii]
AID - animals-14-00545 [pii]
AID - 10.3390/ani14040545 [doi]
PST - epublish
SO  - Animals (Basel). 2024 Feb 6;14(4):545. doi: 10.3390/ani14040545.