PMID- 38396729
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240227
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 4
DP  - 2024 Feb 8
TI  - Mitochondrial Quantity and Quality in Age-Related Sarcopenia.
LID - 10.3390/ijms25042052 [doi]
LID - 2052
AB  - Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a 
      condition with a complex pathophysiology. Among the factors underlying the 
      development of sarcopenia are the progressive demise of motor neurons, the 
      transition from fast to slow myosin isoform (type II to type I fiber switch), and 
      the decrease in satellite cell number and function. Mitochondrial dysfunction has 
      been indicated as a key contributor to skeletal myocyte decline and loss of 
      physical performance with aging. Several systems have been implicated in the 
      regulation of muscle plasticity and trophism such as the fine-tuned and complex 
      regulation between the stimulator of protein synthesis, mechanistic target of 
      rapamycin (mTOR), and the inhibitor of mTOR, AMP-activated protein kinase (AMPK), 
      that promotes muscle catabolism. Here, we provide an overview of the molecular 
      mechanisms linking mitochondrial signaling and quality with muscle homeostasis 
      and performance and discuss the main pathways elicited by their imbalance during 
      age-related muscle wasting. We also discuss lifestyle interventions (i.e., 
      physical exercise and nutrition) that may be exploited to preserve mitochondrial 
      function in the aged muscle. Finally, we illustrate the emerging possibility of 
      rescuing muscle tissue homeostasis through mitochondrial transplantation.
FAU - Marzetti, Emanuele
AU  - Marzetti E
AUID- ORCID: 0000-0001-9567-6983
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 
      00168 Rome, Italy.
AD  - Department of Geriatrics, Orthopedics and Rheumatology, Universita Cattolica del 
      Sacro Cuore, L.go F. Vito 1, 00618 Rome, Italy.
FAU - Calvani, Riccardo
AU  - Calvani R
AUID- ORCID: 0000-0001-5472-2365
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 
      00168 Rome, Italy.
AD  - Department of Geriatrics, Orthopedics and Rheumatology, Universita Cattolica del 
      Sacro Cuore, L.go F. Vito 1, 00618 Rome, Italy.
FAU - Coelho-Junior, Helio Jose
AU  - Coelho-Junior HJ
AUID- ORCID: 0000-0001-7482-9514
AD  - Department of Geriatrics, Orthopedics and Rheumatology, Universita Cattolica del 
      Sacro Cuore, L.go F. Vito 1, 00618 Rome, Italy.
FAU - Landi, Francesco
AU  - Landi F
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 
      00168 Rome, Italy.
AD  - Department of Geriatrics, Orthopedics and Rheumatology, Universita Cattolica del 
      Sacro Cuore, L.go F. Vito 1, 00618 Rome, Italy.
FAU - Picca, Anna
AU  - Picca A
AUID- ORCID: 0000-0001-7032-3487
AD  - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, L.go A. Gemelli 8, 
      00168 Rome, Italy.
AD  - Department of Medicine and Surgery, LUM University, SS100 km 18, 70010 
      Casamassima, Italy.
LA  - eng
GR  - D1.2020/Universita Cattolica del Sacro Cuore/
GR  - D1.2022/Universita Cattolica del Sacro Cuore/
GR  - D1.2023/Universita Cattolica del Sacro Cuore/
GR  - N/A/Centro Studi Achille e Linda Lorenzon/
GR  - DM 1557 11.10.2022/European Commission/
PT  - Journal Article
PT  - Review
DEP - 20240208
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Sarcopenia/metabolism
MH  - Mitochondria/metabolism
MH  - Muscle Fibers, Skeletal/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Muscle, Skeletal/metabolism
PMC - PMC10889427
OTO - NOTNLM
OT  - DAMPs
OT  - extracellular vesicles
OT  - inflammaging
OT  - metabolism
OT  - mitochondrial DNA
OT  - mitochondrial biogenesis
OT  - mitochondrial transplantation
OT  - mitophagy
OT  - muscle aging
OT  - muscle plasticity
COIS- The authors declare no conflicts of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2024/02/24 11:44
MHDA- 2024/02/26 06:42
PMCR- 2024/02/08
CRDT- 2024/02/24 01:03
PHST- 2023/12/19 00:00 [received]
PHST- 2024/02/01 00:00 [revised]
PHST- 2024/02/06 00:00 [accepted]
PHST- 2024/02/26 06:42 [medline]
PHST- 2024/02/24 11:44 [pubmed]
PHST- 2024/02/24 01:03 [entrez]
PHST- 2024/02/08 00:00 [pmc-release]
AID - ijms25042052 [pii]
AID - ijms-25-02052 [pii]
AID - 10.3390/ijms25042052 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Feb 8;25(4):2052. doi: 10.3390/ijms25042052.