PMID- 38396770
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240227
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 4
DP  - 2024 Feb 8
TI  - Chemoradiotherapy and Lymph Node Metastasis Affect Dendritic Cell Infiltration 
      and Maturation in Regional Lymph Nodes of Laryngeal Cancer.
LID - 10.3390/ijms25042093 [doi]
LID - 2093
AB  - Dendritic cells (DCs) are the most specialized antigen-presenting cells, and 
      lymph nodes (LNs) play an important role in the DC-mediated T-cell response. We 
      evaluated the infiltration of CD1a-positive DCs (CD1a-DCs), i.e., immature DCs, 
      and S100-positive dendritic cells (S100-DCs), a mixture of immature and mature 
      DCs, in 73 cases of laryngeal cancer and its regional LNs. Among them, 31 
      patients underwent radiotherapy (RT) or chemoradiotherapy (CRT) prior to surgery. 
      No significant difference was found for CD1a-DC infiltration in the primary 
      tumors, metastatic LNs and non-metastatic LNs, while S100-DCs were significantly 
      fewer in number in the primary tumors and metastatic LNs compared to 
      non-metastatic LNs. The cases which showed a high infiltration of S100-DCs in the 
      metastatic LNs appeared to show a favorable prognosis, although statistical 
      significance was not reached. In the RT/CRT group, the infiltration of the 
      CD1a-DCs and S100-DCs was less in the primary tumors and metastatic LNs compared 
      to the treatment-naive group. Conversely, the RT/CRT group showed higher CD1a-DC 
      and S100-DC numbers in the non-metastatic LNs compared to the treatment-naive 
      group. Thus, DC maturation in metastatic LNs plays an important role in tumor 
      immunity in laryngeal cancer, and the infiltration of DCs into the primary tumor 
      and metastatic LNs is impaired by RT/CRT.
FAU - Kawasaki, Kanako
AU  - Kawasaki K
AD  - Department of Pathology & Microbiology, Faculty of Medicine, Saga University, 
      Saga 849-8501, Japan.
AD  - Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga 
      University, Saga 849-8501, Japan.
FAU - Kai, Keita
AU  - Kai K
AUID- ORCID: 0000-0003-1553-2598
AD  - Department of Pathology, Saga University Hospital, Saga 849-8501, Japan.
FAU - Minesaki, Akimichi
AU  - Minesaki A
AD  - Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga 
      University, Saga 849-8501, Japan.
FAU - Maeda, Sachiko
AU  - Maeda S
AD  - Department of Pathology & Microbiology, Faculty of Medicine, Saga University, 
      Saga 849-8501, Japan.
FAU - Yamauchi, Moriyasu
AU  - Yamauchi M
AUID- ORCID: 0000-0002-7719-4187
AD  - Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga 
      University, Saga 849-8501, Japan.
FAU - Kuratomi, Yuichiro
AU  - Kuratomi Y
AD  - Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Saga 
      University, Saga 849-8501, Japan.
LA  - eng
GR  - 22K16913/Japan Society for the Promotion of Science/
GR  - JS20220057/Soda Toyoji Memorial Foundation/
PT  - Journal Article
DEP - 20240208
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Laryngeal Neoplasms/therapy/pathology
MH  - Lymphatic Metastasis/pathology
MH  - Dendritic Cells
MH  - Lymph Nodes/pathology
MH  - Chemoradiotherapy
PMC - PMC10888629
OTO - NOTNLM
OT  - CD1a
OT  - S100
OT  - chemoradiotherapy
OT  - dendritic cell
OT  - lymph node
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/24 11:45
MHDA- 2024/02/26 06:43
PMCR- 2024/02/08
CRDT- 2024/02/24 01:03
PHST- 2024/01/17 00:00 [received]
PHST- 2024/02/05 00:00 [revised]
PHST- 2024/02/07 00:00 [accepted]
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/24 11:45 [pubmed]
PHST- 2024/02/24 01:03 [entrez]
PHST- 2024/02/08 00:00 [pmc-release]
AID - ijms25042093 [pii]
AID - ijms-25-02093 [pii]
AID - 10.3390/ijms25042093 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Feb 8;25(4):2093. doi: 10.3390/ijms25042093.