PMID- 38397127
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240227
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 4
DP  - 2024 Feb 19
TI  - The Evolving Role of Dendritic Cells in Atherosclerosis.
LID - 10.3390/ijms25042450 [doi]
LID - 2450
AB  - Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, 
      is characterized by chronic inflammation of the arterial wall. This inflammatory 
      process is initiated and maintained by both innate and adaptive immunity. 
      Dendritic cells (DCs), which are antigen-presenting cells, play a crucial role in 
      the development of atherosclerosis and consist of various subtypes with distinct 
      functional abilities. Following the recognition and binding of antigens, DCs 
      become potent activators of cellular responses, bridging the innate and adaptive 
      immune systems. The modulation of specific DC subpopulations can have either 
      pro-atherogenic or atheroprotective effects, highlighting the dual 
      pro-inflammatory or tolerogenic roles of DCs. In this work, we provide a 
      comprehensive overview of the evolving roles of DCs and their subtypes in the 
      promotion or limitation of atherosclerosis development. Additionally, we explore 
      antigen pulsing and pharmacological approaches to modulate the function of DCs in 
      the context of atherosclerosis.
FAU - Britsch, Simone
AU  - Britsch S
AUID- ORCID: 0009-0001-2212-4114
AD  - Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, 
      Centre for Acute Cardiovascular Medicine Mannheim (ZKAM), University Medical 
      Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, 
      Germany.
AD  - German Centre for Cardiovascular Research (DZHK), Partner Site 
      Heidelberg/Mannheim, 13092 Mannheim, Germany.
AD  - European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg 
      University, 68167 Mannheim, Germany.
FAU - Langer, Harald
AU  - Langer H
AD  - Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, 
      Centre for Acute Cardiovascular Medicine Mannheim (ZKAM), University Medical 
      Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, 
      Germany.
AD  - German Centre for Cardiovascular Research (DZHK), Partner Site 
      Heidelberg/Mannheim, 13092 Mannheim, Germany.
AD  - European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg 
      University, 68167 Mannheim, Germany.
FAU - Duerschmied, Daniel
AU  - Duerschmied D
AD  - Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, 
      Centre for Acute Cardiovascular Medicine Mannheim (ZKAM), University Medical 
      Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, 
      Germany.
AD  - German Centre for Cardiovascular Research (DZHK), Partner Site 
      Heidelberg/Mannheim, 13092 Mannheim, Germany.
AD  - European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg 
      University, 68167 Mannheim, Germany.
FAU - Becher, Tobias
AU  - Becher T
AD  - Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, 
      Centre for Acute Cardiovascular Medicine Mannheim (ZKAM), University Medical 
      Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 69117 Mannheim, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240219
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Dendritic Cells
MH  - *Atherosclerosis/metabolism
MH  - Adaptive Immunity
MH  - Inflammation/metabolism
PMC - PMC10888834
OTO - NOTNLM
OT  - adaptive immunity
OT  - atherosclerosis
OT  - dendritic cells
OT  - immune cells
OT  - inflammation
OT  - innate immunity
COIS- T.B. is an employee and shareholder of Roche Diagnostics International, Rotkreuz, 
      Switzerland. All other authors declare that they do not have a conflict of 
      interest.
EDAT- 2024/02/24 11:43
MHDA- 2024/02/26 06:43
PMCR- 2024/02/19
CRDT- 2024/02/24 01:05
PHST- 2023/12/06 00:00 [received]
PHST- 2024/02/01 00:00 [revised]
PHST- 2024/02/13 00:00 [accepted]
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/24 11:43 [pubmed]
PHST- 2024/02/24 01:05 [entrez]
PHST- 2024/02/19 00:00 [pmc-release]
AID - ijms25042450 [pii]
AID - ijms-25-02450 [pii]
AID - 10.3390/ijms25042450 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Feb 19;25(4):2450. doi: 10.3390/ijms25042450.