PMID- 38397263
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 11
IP  - 2
DP  - 2024 Jan 24
TI  - Research on the Clinical Practical Use of Pivoxil-Conjugated Antibodies and the 
      Risk of Carnitine Deficiency Using Real-World Data.
LID - 10.3390/children11020150 [doi]
LID - 150
AB  - In Japan, pivoxil-conjugated antibodies (PVs) are commonly used to treat 
      infections. However, carnitine deficiency is a known adverse drug reaction 
      associated with PV treatment. This study aimed to research the practical use of 
      PV and assess the risk of carnitine deficiency in patients receiving PV compared 
      to their amoxicillin (AM)-treated counterparts. The Pediatric Medical Information 
      Collection System (P-MICS) served as the data source for this study. The study 
      cohort comprised patients aged 0-15 years prescribed PV between April 2016 and 
      March 2021. Data on the actual PV prescriptions were extracted for each patient. 
      To evaluate the risk of carnitine deficiency, adverse events (AEs) were defined 
      as carnitine deficiency and its associated symptoms. Propensity score matching 
      was employed to compare the AE incidence between the PV and AM groups. The number 
      of cases of PV prescriptions decreased year-on-year between 2016 and 2021, and 
      >80% of prescriptions were dispensed in the clinic. The propensity score matching 
      analysis demonstrated no statistically significant difference in the incidence of 
      carnitine deficiency and its associated symptoms between the PV and AM groups. 
      Our findings suggest that the risk of carnitine deficiency in children treated 
      with PV is not significantly higher than that associated with other antibiotics.
FAU - Suzuki-Yoshida, Kaho
AU  - Suzuki-Yoshida K
AD  - Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 
      Tokyo 204-0004, Japan.
AD  - Department of Pharmacy, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
AD  - MSD K.K., Tokyo 102-8667, Japan.
FAU - Nakano, Kosuke
AU  - Nakano K
AD  - Clinical Research Center, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
FAU - Nakakuni, Masayoshi
AU  - Nakakuni M
AD  - Clinical Research Center, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
FAU - Deguchi, Naoko
AU  - Deguchi N
AD  - Clinical Research Center, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
FAU - Mitsui, Seiji
AU  - Mitsui S
AD  - Clinical Research Center, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
FAU - Kobayashi, Shinji
AU  - Kobayashi S
AD  - Nature Insight Co., Ltd., Tokyo 101-0021, Japan.
FAU - Yamatani, Akimasa
AU  - Yamatani A
AD  - Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 
      Tokyo 204-0004, Japan.
AD  - Department of Pharmacy, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
FAU - Akabane, Miki
AU  - Akabane M
AD  - Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 
      Tokyo 204-0004, Japan.
AD  - Department of Pharmacy, National Center for Child Health and Development, Tokyo 
      157-8535, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240124
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10887142
OTO - NOTNLM
OT  - carnitine deficiency
OT  - children
OT  - pivoxil-conjugated antibodies
OT  - real-world data
COIS- Author Shinji Kobayashi was employed by the company Nature Insight Co., Ltd. 
      Author Kaho Suzuki-Yoshida was employed by the company MSD K.K. The remaining 
      authors declare that the research was conducted in the absence of any commercial 
      or financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2024/02/24 11:43
MHDA- 2024/02/24 11:44
PMCR- 2024/01/24
CRDT- 2024/02/24 01:06
PHST- 2024/01/05 00:00 [received]
PHST- 2024/01/17 00:00 [revised]
PHST- 2024/01/20 00:00 [accepted]
PHST- 2024/02/24 11:44 [medline]
PHST- 2024/02/24 11:43 [pubmed]
PHST- 2024/02/24 01:06 [entrez]
PHST- 2024/01/24 00:00 [pmc-release]
AID - children11020150 [pii]
AID - children-11-00150 [pii]
AID - 10.3390/children11020150 [doi]
PST - epublish
SO  - Children (Basel). 2024 Jan 24;11(2):150. doi: 10.3390/children11020150.