PMID- 38397668
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240308
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 21
IP  - 2
DP  - 2024 Feb 4
TI  - Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 
      2 Diabetes Mellitus: A Scoping Minireview.
LID - 10.3390/ijerph21020177 [doi]
LID - 177
AB  - Type 2 diabetes mellitus (T2DM) is a public health condition where environmental 
      and genetic factors can intersect through hydroxymethylation. It was unclear 
      which blood DNA regions were hydroxymethylated in human T2DM development. We 
      aimed to identify the regions from the literature as designed in the ongoing 
      Twins Discordant for Incident T2DM Study. A scoping review was performed using 
      Medical Subject Headings (MeSH) and keyword methods to search PubMed for studies 
      published in English and before 1 August 2022, following our registered protocol. 
      The keyword and MeSH methods identified 12 and 3 records separately, and the 
      keyword-identified records included all from the MeSH. Only three case-control 
      studies met the criteria for the full-text review, including one MeSH-identified 
      record. Increased global levels of 5-hydroxymethylated cytosine (5hmC) in T2DM 
      patients versus healthy controls in blood or peripheral blood mononuclear cells 
      were consistently reported (p < 0.05 for all). Among candidate DNA regions 
      related to the human SOCS3, SREBF1, and TXNIP genes, only the SOCS3 gene yielded 
      higher 5hmC levels in T2DM patients with high poly-ADP-ribosylation than 
      participants combined from those with low PARylation and healthy controls (p < 
      0.05). Hydroxymethylation in the SOCS3-related region of blood DNA is promising 
      to investigate for its mediation in the influences of environment on incident 
      T2DM.
FAU - Luong, Ryan Anh Minh
AU  - Luong RAM
AD  - Doctoral Program of Osteopathic Medicine, College of Osteopathic Medicine, Des 
      Moines University, West Des Moines, IA 50266, USA.
FAU - Guan, Weihua
AU  - Guan W
AD  - Division of Biostatistics & Health Data Science, University of Minnesota School 
      of Public Health, Minneapolis, MN 55414, USA.
FAU - Vue, Fue Chee
AU  - Vue FC
AD  - Doctoral Program of Osteopathic Medicine, College of Osteopathic Medicine, Des 
      Moines University, West Des Moines, IA 50266, USA.
FAU - Dai, Jun
AU  - Dai J
AUID- ORCID: 0000-0001-7930-2885
AD  - Department of Public Health, College of Health Sciences, Des Moines University, 
      West Des Moines, IA 50266, USA.
LA  - eng
GR  - R15 HL152330/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20240204
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Leukocytes, Mononuclear
MH  - DNA
MH  - DNA Methylation
MH  - Case-Control Studies
PMC - PMC10887687
OTO - NOTNLM
OT  - blood
OT  - human
OT  - hydroxymethylation
OT  - peripheral
OT  - twin
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/24 11:45
MHDA- 2024/02/26 06:43
PMCR- 2024/02/04
CRDT- 2024/02/24 01:08
PHST- 2024/01/05 00:00 [received]
PHST- 2024/01/31 00:00 [revised]
PHST- 2024/02/02 00:00 [accepted]
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/24 11:45 [pubmed]
PHST- 2024/02/24 01:08 [entrez]
PHST- 2024/02/04 00:00 [pmc-release]
AID - ijerph21020177 [pii]
AID - ijerph-21-00177 [pii]
AID - 10.3390/ijerph21020177 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2024 Feb 4;21(2):177. doi: 
      10.3390/ijerph21020177.