PMID- 38397744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 13
IP  - 2
DP  - 2024 Jan 24
TI  - Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of 
      Lamiaceae Plants for the Treatment of Fibrosis of Various Organs.
LID - 10.3390/antiox13020146 [doi]
LID - 146
AB  - Fibrosis, which causes structural hardening and functional degeneration in 
      various organs, is characterized by the excessive production and accumulation of 
      connective tissue containing collagen, alpha-smooth muscle actin (alpha-SMA), etc. In 
      traditional medicine, extracts of medicinal plants or herbal prescriptions have 
      been used to treat various fibrotic diseases. The purpose of this narrative 
      review is to discuss the antifibrotic effects of rosmarinic acid (RA) and plant 
      extracts that contain RA, as observed in various experimental models. RA, as well 
      as the extracts of Glechoma hederacea, Melissa officinalis, Elsholtzia ciliata, 
      Lycopus lucidus, Ocimum basilicum, Prunella vulgaris, Salvia rosmarinus 
      (Rosmarinus officinalis), Salvia miltiorrhiza, and Perilla frutescens, have been 
      shown to attenuate fibrosis of the liver, kidneys, heart, lungs, and abdomen in 
      experimental animal models. Their antifibrotic effects were associated with the 
      attenuation of oxidative stress, inflammation, cell activation, 
      epithelial-mesenchymal transition, and fibrogenic gene expression. RA treatment 
      activated peroxisomal proliferator-activated receptor gamma (PPARgamma), 5' 
      AMP-activated protein kinase (AMPK), and nuclear factor erythroid 2-related 
      factor 2 (NRF2) while suppressing the transforming growth factor beta (TGF-beta) and 
      Wnt signaling pathways. Interestingly, most plants that are reported to contain 
      RA and exhibit antifibrotic activity belong to the family Lamiaceae. This 
      suggests that RA is an active ingredient for the antifibrotic effect of Lamiaceae 
      plants and that these plants are a useful source of RA. In conclusion, 
      accumulating scientific evidence supports the effectiveness of RA and Lamiaceae 
      plant extracts in alleviating fibrosis and maintaining the structural 
      architecture and normal functions of various organs under pathological 
      conditions.
FAU - Boo, Yong Chool
AU  - Boo YC
AUID- ORCID: 0000-0001-9895-2066
AD  - Department of Molecular Medicine, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      The Graduate School, Kyungpook National University, 680 Gukchaebosang-ro, 
      Jung-gu, Daegu 41944, Republic of Korea.
AD  - Cell and Matrix Research Institute, Kyungpook National University, 680 
      Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
LA  - eng
GR  - HP20C0004/Korea Health Industry Development Institute/Republic of Korea
PT  - Journal Article
PT  - Review
DEP - 20240124
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10886237
OTO - NOTNLM
OT  - 5' AMP-activated protein kinase
OT  - AMPK
OT  - Lamiaceae
OT  - NRF2
OT  - PPARgamma
OT  - TGF-beta1
OT  - Wnt
OT  - erythroid 2-related factor 2
OT  - fibrosis
OT  - peroxisomal proliferator-activated receptor gamma
OT  - rosmarinic acid
OT  - transforming growth factor beta1
COIS- The author declares no conflicts of interest.
EDAT- 2024/02/24 11:43
MHDA- 2024/02/24 11:44
PMCR- 2024/01/24
CRDT- 2024/02/24 01:09
PHST- 2023/12/11 00:00 [received]
PHST- 2024/01/22 00:00 [revised]
PHST- 2024/01/23 00:00 [accepted]
PHST- 2024/02/24 11:44 [medline]
PHST- 2024/02/24 11:43 [pubmed]
PHST- 2024/02/24 01:09 [entrez]
PHST- 2024/01/24 00:00 [pmc-release]
AID - antiox13020146 [pii]
AID - antioxidants-13-00146 [pii]
AID - 10.3390/antiox13020146 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2024 Jan 24;13(2):146. doi: 10.3390/antiox13020146.