PMID- 38397984
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240227
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 12
IP  - 2
DP  - 2024 Feb 7
TI  - In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower 
      Transcutaneous Oxygen Pressure in Type 2 Diabetes.
LID - 10.3390/biomedicines12020381 [doi]
LID - 381
AB  - Type 2 diabetes mellitus (T2DM) significantly increases the risk of peripheral 
      artery disease (PAD), and diabetes is the leading cause of nontraumatic 
      amputations. This study investigated the risk factors for transcutaneous oxygen 
      pressure (TcPO2) in T2DM, a noninvasive method to quantify skin oxygenation and 
      the underlying microvascular circulation. The study included 119 T2DM patients 
      (91 male/28 female). TcPO2 measurements were conducted with the Tina TCM4 Series 
      transcutaneous monitor (Radiometer, Copenhagen, Sweden) and skin electrodes. 
      Patients with TcPO2 < 40 mmHg were younger (p = 0.001), had significantly higher 
      systolic blood pressure (SBP) (p = 0.023), glycated hemoglobin (HbA(1)c) (p = 
      0.013), fasting plasma glucose (fPG) (p = 0.038), total cholesterol (p = 0.006), 
      LDL cholesterol (p = 0.004), and had more frequent smoking habits (p = 0.001) 
      than those with TcPO2 >/= 40 mmHg. The main predictors for the TcPO2 value (R(2) = 
      0.211) obtained via stepwise regression analysis were age, smoking, SBP, HbA(1)c, 
      fPG, and total and LDL cholesterol. Among all the listed predictors, smoking, 
      HbA(1)c, and LDL cholesterol were found to be the most significant, with negative 
      parameter estimates of -3.051310 (p = 0.0007), -2.032018 (p = 0.0003), and 
      -2.560353 (p = 0.0046). The results of our study suggest that in association with 
      other risk factors, smoking is the main predictor for lower TcPO2 in T2DM.
FAU - Bulum, Tomislav
AU  - Bulum T
AUID- ORCID: 0000-0003-4808-2968
AD  - Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, 
      Merkur University Hospital, 10000 Zagreb, Croatia.
AD  - School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
FAU - Brkljacic, Neva
AU  - Brkljacic N
AD  - Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, 
      Merkur University Hospital, 10000 Zagreb, Croatia.
FAU - Ticinovic Ivancic, Angelika
AU  - Ticinovic Ivancic A
AD  - Zagreb Country Public Health Institute, 10430 Samobor, Croatia.
FAU - Cavlovic, Maja
AU  - Cavlovic M
AD  - Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, 
      Merkur University Hospital, 10000 Zagreb, Croatia.
FAU - Prkacin, Ingrid
AU  - Prkacin I
AD  - School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
AD  - Department of Internal Medicine, Merkur University Hospital, 10000 Zagreb, 
      Croatia.
FAU - Tomic, Martina
AU  - Tomic M
AUID- ORCID: 0000-0002-7535-3631
AD  - Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, 
      Merkur University Hospital, 10000 Zagreb, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20240207
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10886561
OTO - NOTNLM
OT  - atherosclerosis
OT  - peripheral artery disease
OT  - smoking
OT  - transcutaneous oxygen pressure
OT  - type 2 diabetes
COIS- All authors declare no competing interests.
EDAT- 2024/02/24 11:45
MHDA- 2024/02/24 11:46
PMCR- 2024/02/07
CRDT- 2024/02/24 01:10
PHST- 2024/01/08 00:00 [received]
PHST- 2024/02/01 00:00 [revised]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/02/24 11:46 [medline]
PHST- 2024/02/24 11:45 [pubmed]
PHST- 2024/02/24 01:10 [entrez]
PHST- 2024/02/07 00:00 [pmc-release]
AID - biomedicines12020381 [pii]
AID - biomedicines-12-00381 [pii]
AID - 10.3390/biomedicines12020381 [doi]
PST - epublish
SO  - Biomedicines. 2024 Feb 7;12(2):381. doi: 10.3390/biomedicines12020381.