PMID- 38400544
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 41
IP  - 2
DP  - 2024 Feb
TI  - Acute changes in cardiac dimensions, function, and longitudinal mechanics in 
      healthy individuals with and without high-altitude induced pulmonary hypertension 
      at 4559 m.
PG  - e15786
LID - 10.1111/echo.15786 [doi]
AB  - BACKGROUND: High-altitude pulmonary hypertension (HAPH) has a prevalence of 
      approximately 10%. Changes in cardiac morphology and function at high altitude, 
      compared to a population that does not develop HAPH are scarce. METHODS: Four 
      hundred twenty-one subjects were screened in a hypoxic chamber inspiring a 
      FiO(2 ) = 12% for 2 h. In 33 subjects an exaggerated increase in systolic 
      pulmonary artery pressure (sPAP) could be confirmed in two independent 
      measurements. Twenty nine of these, and further 24 matched subjects without sPAP 
      increase were examined at 4559 m by Doppler echocardiography including global 
      longitudinal strain (GLS). RESULTS: SPAP increase was higher in HAPH subjects 
      (∆ = 10.2 vs. ∆ = 32.0 mm Hg, p < .001). LV eccentricity index (∆ = .15 vs. 
      ∆ = .31, p = .009) increased more in HAPH. D-shaped LV (0 [0%] vs. 30 [93.8%], 
      p = .00001) could be observed only in the HAPH group, and only in those with a 
      sPAP >/=50 mm Hg. LV-EF (∆ = 4.5 vs. ∆ = 6.7%, p = .24) increased in both groups. 
      LV-GLS (∆ = 1.2 vs. ∆ = 1.1 -%, p = .60) increased slightly. RV end-diastolic 
      (∆ = 2.20 vs. ∆ = 2.7 cm(2) , p = .36) and end-systolic area (∆ = 2.1 vs. 
      ∆ = 2.7 cm(2) , p = .39), as well as RA end-systolic area index (∆ = -.9 vs. 
      ∆ = .3 cm(2) /m(2) , p = .01) increased, RV-FAC (∆ = -2.9 vs. ∆ = -4.7%, p = .43) 
      decreased, this was more pronounced in HAPH, RV-GLS (∆ = 1.6 vs. ∆ = -.7 -%, 
      p = .17) showed marginal changes. CONCLUSIONS: LV and LA dimensions decrease and 
      left ventricular function increases at high-altitude in subjects with and without 
      HAPH. RV and RA dimensions increase, and RV longitudinal strain increases or 
      remains unchanged in subjects with HAPH. Changes are negligible in those without 
      HAPH.
CI  - (c) 2024 The Authors. Echocardiography published by Wiley Periodicals LLC.
FAU - Mereles, Derliz
AU  - Mereles D
AUID- ORCID: 0000-0001-9601-7103
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Rudolph, Jens
AU  - Rudolph J
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Greiner, Sebastian
AU  - Greiner S
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Aurich, Matthias
AU  - Aurich M
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Frey, Norbert
AU  - Frey N
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Katus, Hugo A
AU  - Katus HA
AD  - Internal Medicine III, Cardiology, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Bartsch, Peter
AU  - Bartsch P
AD  - Internal Medicine VII, Sports Medicine, University Hospital Heidelberg, 
      Heidelberg, Germany.
FAU - Dehnert, Christoph
AU  - Dehnert C
AD  - Internal Medicine VII, Sports Medicine, University Hospital Heidelberg, 
      Heidelberg, Germany.
AD  - University Centre for Prevention and Sports Medicine, University Clinic Balgrist, 
      University of Zurich, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Humans
MH  - *Hypertension, Pulmonary/diagnostic imaging/etiology
MH  - Altitude
MH  - *Altitude Sickness/complications
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Doppler echocardiography
OT  - high-altitude
OT  - hypoxia-chamber echocardiography
OT  - longitudinal strain
OT  - pulmonary hypertension
EDAT- 2024/02/24 11:43
MHDA- 2024/02/26 06:43
CRDT- 2024/02/24 02:39
PHST- 2024/02/05 00:00 [revised]
PHST- 2023/12/21 00:00 [received]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/24 11:43 [pubmed]
PHST- 2024/02/24 02:39 [entrez]
AID - 10.1111/echo.15786 [doi]
PST - ppublish
SO  - Echocardiography. 2024 Feb;41(2):e15786. doi: 10.1111/echo.15786.