PMID- 38401404 OWN - NLM STAT- MEDLINE DCOM- 20240315 LR - 20240315 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 257 DP - 2024 Apr TI - Association between prenatal exposure to per- and polyfluoroalkyl substances and infant anthropometry: A prospective cohort study. PG - 114339 LID - S1438-4639(24)00020-8 [pii] LID - 10.1016/j.ijheh.2024.114339 [doi] AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic organic chemicals with potential endocrine-disrupting effects, and have been found to impair the physical growth of offspring in both experimental and epidemiological studies. We aimed to investigate the effects of prenatal PFAS exposure on repeated measurements of multiple anthropometric indicators in infants. METHOD: PFAS were measured in serum samples collected from pregnant women at 12-16 gestational weeks. We calculated z-scores for the weight-for-age (WAZ), weight-for-length (WLZ), head circumference-for-age (HCZ), arm circumference-for-age (ACZ), triceps skinfold-for-age (TSZ), and subscapular skinfold-for-age (SSZ) at birth, 6 months, and 12 months of age according to the child growth standards of the World Health Organization (WHO) for anthropometric indicators. A total of 964 mother-infant pairs were included. A multivariate linear regression was performed to examine the associations between prenatal PFAS concentrations and anthropometric indicators at each time point. A generalized estimating equation (GEE) model was used to examine the longitudinal effects of PFAS exposure on repeated measurements of anthropometric indicators. Ultimately, a Bayesian kernel machine regression (BKMR) model was used to assess the joint effects of the PFAS mixture on anthropometric indicators. RESULTS: In GEE models, perfluorododecanoic acid (PFDoA) in the high tertile group was associated with increased WAZ/WLZ, with beta values (95% confidence intervals (CI)) of 0.12 (0.00, 0.23) and 0.18 (0.03, 0.32), respectively. Per fl uorononanoic acid (PFNA) was associated with increased ACZ in the middle and high tertile groups. The BKMR models also presented the associations of the PFAS mixture with increased WAZ/WLZ throughout infancy, with more profound effects in females. Meanwhile, a pattern of inverse associations was observed between the perfluorooctanoic acid (PFOA) concentrations in the high tertile group and decreased WAZ, WLZ, and HCZ in males. In addition, the associations between PFAS and increased TSZ/SSZ at birth were identified by both linear regression and BKMR models. CONCLUSION: Prenatal PFAS exposure (PFNA and PFDoA) was associated with increased infant anthropometry, especially in female infants, while prenatal PFOA exposure was associated with decreased weight, and head and arm circumference in male infants. The findings indicate that prenatal PFAS exposure may impair the growth trajectory of offspring. CI - Copyright (c) 2024 Elsevier GmbH. All rights reserved. FAU - Li, Jincan AU - Li J AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Department of Public Health, Fudan University, Shanghai, 200237, China. FAU - Su, Xiujuan AU - Su X AD - Clinical Research Centre, Shanghai Key Laboratory of Maternal Foetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. FAU - Zhou, Yan AU - Zhou Y AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China. FAU - Ji, Honglei AU - Ji H AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Xie, Zhenzhen AU - Xie Z AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Department of Public Health, Fudan University, Shanghai, 200237, China. FAU - Sun, Songlin AU - Sun S AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Department of Public Health, Fudan University, Shanghai, 200237, China. FAU - Wang, Ziliang AU - Wang Z AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Yuan, Wei AU - Yuan W AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Miao, Maohua AU - Miao M AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Liang, Hong AU - Liang H AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. Electronic address: lianghong@sibpt.com. LA - eng PT - Journal Article DEP - 20240223 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - P6G1J7NM2D (perfluorododecanoic acid) RN - 375-95-1 (perfluoro-n-nonanoic acid) RN - 0 (Alkanesulfonic Acids) RN - 0 (Fatty Acids) RN - 0 (Lauric Acids) SB - IM MH - Infant, Newborn MH - Infant MH - Child MH - Humans MH - Male MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects MH - Prospective Studies MH - Bayes Theorem MH - *Environmental Pollutants MH - Anthropometry MH - *Fluorocarbons MH - *Alkanesulfonic Acids MH - *Fatty Acids MH - *Lauric Acids OTO - NOTNLM OT - Infancy OT - Per- and polyfluoroalkyl substances OT - Postnatal growth OT - Prenatal exposure OT - Prospective study COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/02/25 00:42 MHDA- 2024/03/15 06:43 CRDT- 2024/02/24 18:12 PHST- 2023/05/17 00:00 [received] PHST- 2024/01/19 00:00 [revised] PHST- 2024/02/13 00:00 [accepted] PHST- 2024/03/15 06:43 [medline] PHST- 2024/02/25 00:42 [pubmed] PHST- 2024/02/24 18:12 [entrez] AID - S1438-4639(24)00020-8 [pii] AID - 10.1016/j.ijheh.2024.114339 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2024 Apr;257:114339. doi: 10.1016/j.ijheh.2024.114339. Epub 2024 Feb 23.