PMID- 38401823
OWN - NLM
STAT- MEDLINE
DCOM- 20240402
LR  - 20240402
IS  - 1535-6280 (Electronic)
IS  - 0146-2806 (Linking)
VI  - 49
IP  - 5
DP  - 2024 May
TI  - The roles of C-reactive protein-albumin ratio as a novel prognostic biomarker in 
      heart failure patients: A systematic review.
PG  - 102475
LID - S0146-2806(24)00114-2 [pii]
LID - 10.1016/j.cpcardiol.2024.102475 [doi]
AB  - C-Reactive Protein (CRP)-albumin ratio (CAR) is a novel prognostic biomarker that 
      is predicted to be a more reliable indicator than CRP or albumin alone. 
      Therefore, this systematic review aimed to evaluate the role of CAR in predicting 
      poor outcomes of heart failure (HF) patients. We conducted a literature search 
      across ProQuest, PubMed, ScienceDirect, Web of Science, and Scopus. All related 
      studies assessing CAR and reporting mortality outcomes or other adverse outcomes 
      were assessed. A total of five studies with a total of 1821 patients were 
      included in this review. CAR is significantly associated with all-causes 
      in-hospital mortality and out-hospital mortality in patients with acute and 
      chronic heart failure. CAR is associated with higher hospitalization rates, the 
      number of hospitalizations, severe New York Heart Association (NYHA) 
      classification, and the risk of advanced HF. In conclusion, CAR is significantly 
      associated with poor HF outcomes including all-cause mortality (cardiac and 
      non-cardiac death).
CI  - Copyright (c) 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Kurniawan, Roy Bagus
AU  - Kurniawan RB
AD  - Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
FAU - Oktafia, Pratista
AU  - Oktafia P
AD  - Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
FAU - Saputra, Pandit Bagus Tri
AU  - Saputra PBT
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas 
      Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, East Java, 
      Indonesia; Cardiovascular Research and Innovation Center, Universitas Airlangga, 
      Surabaya, East Java, Indonesia.
FAU - Purwati, Dinda Dwi
AU  - Purwati DD
AD  - Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
FAU - Saputra, Mahendra Eko
AU  - Saputra ME
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas 
      Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, East Java, 
      Indonesia; Cardiovascular Research and Innovation Center, Universitas Airlangga, 
      Surabaya, East Java, Indonesia.
FAU - Maghfirah, Irma
AU  - Maghfirah I
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas 
      Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, East Java, 
      Indonesia; Cardiovascular Research and Innovation Center, Universitas Airlangga, 
      Surabaya, East Java, Indonesia.
FAU - Faizah, Novia Nurul
AU  - Faizah NN
AD  - Division of Cardiovascular Medicine, Graduate School of Medicine, Kobe 
      University, Kobe, Japan.
FAU - Oktaviono, Yudi Her
AU  - Oktaviono YH
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas 
      Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, East Java, 
      Indonesia; Cardiovascular Research and Innovation Center, Universitas Airlangga, 
      Surabaya, East Java, Indonesia. Electronic address: yudi.her@fk.unair.ac.id.
FAU - Alkaff, Firas Farisi
AU  - Alkaff FF
AD  - Division of Nephrology, Department of Internal Medicine, University of Groningen, 
      University Medical Center Groningen, Groningen, The Netherlands; Division of 
      Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, 
      Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Electronic 
      address: firasfarisialkaff@fk.unair.ac.id.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20240222
PL  - Netherlands
TA  - Curr Probl Cardiol
JT  - Current problems in cardiology
JID - 7701802
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *C-Reactive Protein
MH  - Prognosis
MH  - Albumins
MH  - *Heart Failure/diagnosis
MH  - Biomarkers
OTO - NOTNLM
OT  - Adverse outcome
OT  - CRP-albumin ratio
OT  - Heart failure
OT  - Mortality
OT  - Prognostic
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/25 00:42
MHDA- 2024/04/02 06:45
CRDT- 2024/02/24 19:18
PHST- 2024/02/16 00:00 [received]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/04/02 06:45 [medline]
PHST- 2024/02/25 00:42 [pubmed]
PHST- 2024/02/24 19:18 [entrez]
AID - S0146-2806(24)00114-2 [pii]
AID - 10.1016/j.cpcardiol.2024.102475 [doi]
PST - ppublish
SO  - Curr Probl Cardiol. 2024 May;49(5):102475. doi: 10.1016/j.cpcardiol.2024.102475. 
      Epub 2024 Feb 22.