PMID- 38403822
OWN - NLM
STAT- Publisher
LR  - 20240225
IS  - 1863-6713 (Electronic)
IS  - 1863-6705 (Linking)
DP  - 2024 Feb 26
TI  - Early thrombus formation including hypo-attenuated leaflet thrombosis after 
      surgical bioprosthetic aortic valve replacement.
LID - 10.1007/s11748-024-02010-4 [doi]
AB  - OBJECTIVE: To assess the occurrence, predictors, and outcomes of hypo-attenuated 
      leaflet thickening (HALT) and thrombus outside the prosthetic valve following 
      surgical aortic valve replacement. METHODS: A total of 118 patients underwent 
      surgical aortic valve replacement with bioprosthetic valves between July 2020 and 
      June 2022. Sixty-two (52.5%) patients, which is a fairly high number of patients, 
      underwent cardiac computed tomography and transthoracic echocardiography one week 
      after surgery. Patients were divided into two groups, those with HALT (n = 14) 
      and those without HALT (n = 48). RESULTS: Of the 62 patients who underwent 
      cardiac computed tomography, HALT was observed in 14 (22.5%) patients during the 
      very early postoperative phase. Reduced leaflet motion was observed in two of the 
      14 patients. The low-attenuation areas were located outside the prosthetic valve 
      in 10 cases (71.4%) in the HALT group and in 14 cases (29.2%) in the non-HALT 
      group. More than 50% of patients (57.1%) with HALT and 79.2% without HALT were 
      administered warfarin. Neither in-hospital deaths nor postoperative 
      thromboembolic events were observed during hospitalization. No patient had a mean 
      pressure gradient > 20 mmHg in either group. CONCLUSION: HALT was observed in 
      one-fifth of the cases after surgical aortic valve replacement during the very 
      early postoperative phase in an institution wherein administration of continuous 
      heparin infusion after surgery is a standard practice. HALT did not affect the 
      early prognosis or incidence of cerebral infarction.
CI  - (c) 2024. The Author(s), under exclusive licence to The Japanese Association for 
      Thoracic Surgery.
FAU - Kono, Takanori
AU  - Kono T
AUID- ORCID: 0000-0001-7984-8706
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. 
      kono_takanori@med.kurume-u.ac.jp.
FAU - Takagi, Kazuyoshi
AU  - Takagi K
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Takaseya, Tohru
AU  - Takaseya T
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Fukuda, Tomofumi
AU  - Fukuda T
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Saku, Kosuke
AU  - Saku K
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Zaima, Yasuyuki
AU  - Zaima Y
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Shojima, Takahiro
AU  - Shojima T
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Arinaga, Koichi
AU  - Arinaga K
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Tayama, Eiki
AU  - Tayama E
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kurume University 
      School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240226
PL  - Japan
TA  - Gen Thorac Cardiovasc Surg
JT  - General thoracic and cardiovascular surgery
JID - 101303952
SB  - IM
OTO - NOTNLM
OT  - Aortic valve replacement
OT  - Bioprosthetic valve
OT  - Hypo-attenuated leaflet thrombosis
EDAT- 2024/02/26 00:42
MHDA- 2024/02/26 00:42
CRDT- 2024/02/25 23:43
PHST- 2023/08/22 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/02/26 00:42 [medline]
PHST- 2024/02/26 00:42 [pubmed]
PHST- 2024/02/25 23:43 [entrez]
AID - 10.1007/s11748-024-02010-4 [pii]
AID - 10.1007/s11748-024-02010-4 [doi]
PST - aheadofprint
SO  - Gen Thorac Cardiovasc Surg. 2024 Feb 26. doi: 10.1007/s11748-024-02010-4.