PMID- 38404967 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240227 IS - 1970-5565 (Print) IS - 1970-5557 (Electronic) IS - 1970-5557 (Linking) VI - 18 DP - 2024 TI - Management of Neuroendocrine Breast Carcinoma (NEBC): Review of Literature. PG - 12114 LID - 10.3389/or.2024.12114 [doi] LID - 12114 AB - Extra pulmonary high-grade poorly differentiated neuroendocrine carcinomas (EP-NECs) are rare tumors that usually arise in the gastrointestinal and genitourinary tracts. Primary neuroendocrine carcinoma of the breast (NEBC) is extremely rare, representing less than 0.1% of all breast cancers and less than 1% of neuroendocrine neoplasms. Consequently, they can be misdiagnosed as other types of breast cancer, however, proper immunohistochemical (IHC) studies can assist with making the correct diagnosis. Management of NEBC can be challenging given the paucity of evidence-based literature and should not routinely follow the therapeutic guidelines of other breast cancers. In this article, we review the current literature regarding the management of NEBC. CI - Copyright (c) 2024 Mohamed, Zeidalkilani, Asa, Trybula and Montero. FAU - Mohamed, A AU - Mohamed A AD - Division of Hematology and Medical Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH, United States. FAU - Zeidalkilani, J AU - Zeidalkilani J AD - Department of Medicine, University Hospitals Seidman Cancer Center, Cleveland, OH, United States. FAU - Asa, S L AU - Asa SL AD - Department of Pathology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, United States. FAU - Trybula, M AU - Trybula M AD - Division of Hematology and Medical Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH, United States. FAU - Montero, Alberto J AU - Montero AJ AD - Division of Hematology and Medical Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH, United States. LA - eng PT - Journal Article PT - Review DEP - 20240209 PL - Switzerland TA - Oncol Rev JT - Oncology reviews JID - 101519906 PMC - PMC10884130 OTO - NOTNLM OT - breast OT - carcinoma OT - management OT - neuroendocrine OT - review COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/02/26 06:43 MHDA- 2024/02/26 06:44 PMCR- 2024/02/09 CRDT- 2024/02/26 04:35 PHST- 2023/09/25 00:00 [received] PHST- 2024/01/15 00:00 [accepted] PHST- 2024/02/26 06:44 [medline] PHST- 2024/02/26 06:43 [pubmed] PHST- 2024/02/26 04:35 [entrez] PHST- 2024/02/09 00:00 [pmc-release] AID - 12114 [pii] AID - 10.3389/or.2024.12114 [doi] PST - epublish SO - Oncol Rev. 2024 Feb 9;18:12114. doi: 10.3389/or.2024.12114. eCollection 2024.